Document Detail


Chemotherapy using intra-arterial infusion for oral cancer.
MedLine Citation:
PMID:  16967775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are three historically recognized methods of intra-arterial infusion for oral cancer: Conventional intra-arterial infusion via the superficial temporal artery: Superselective intra-arterial infusion via the femoral artery (Seldinger method), New superselective intra-arterial infusion via the superficial temporal artery. Here we report a recent instance of daily concurrent chemoradiotherapy using a new superselective intra-arterial infusion. A catheter with a curved tip was inserted superselectively into the feeding artery of the tumor via the superficial temporal artery (long-term catheterization has become possible using this method). The patient with T3 tongue cancer was treated by chemoradiotherapy. Radiotherapy (total dose: 40 Gy/4weeks) and superselective intra-arterial infusion chemotherapy using docetaxel (DOC) (total dose: 60 mg/m2/4weeks, 15 mg/m2/week) and cisplatin (CDDP) (total dose: 100 mg/m2/4weeks, 5 mg/m2/day) were concurrently performed daily, followed by surgery, after which no major complication was observed. The clinical effect was complete response (CR), and the pathological effect on the resected tumor after surgery was pathological CR. This method promises to be a new strategy of choice for the treatment of oral cancer.
Authors:
Iwai Tohnai
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Nagoya journal of medical science     Volume:  68     ISSN:  0027-7622     ISO Abbreviation:  Nagoya J Med Sci     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-09-13     Completed Date:  2006-10-17     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0412011     Medline TA:  Nagoya J Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  101-8     Citation Subset:  IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Japan. tohnai@yokohama-cu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / administration & dosage*
Cisplatin / administration & dosage
Femoral Artery
Humans
Infusions, Intra-Arterial
Male
Middle Aged
Mouth Neoplasms / drug therapy*
Taxoids / administration & dosage
Temporal Arteries
Tongue Neoplasms / drug therapy
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Taxoids; 15663-27-1/Cisplatin; 15H5577CQD/docetaxel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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