| Chemotherapy response assessment in stage IV melanoma patients-comparison of 18F-FDG-PET/CT, CT, brain MRI, and tumormarker S-100B. | |
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MedLine Citation:
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PMID: 18458901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study aims to compare the use of 18F-FDG-PET/CT, CT, brain MRI, and tumormarker S-100B in chemotherapy response assessment of stage IV melanoma patients. METHODS: In 25 patients with stage IV melanoma, FDG-PET/CT and S-100B after 2-3 months (three cycles) of chemotherapy was compared with baseline PET/CT and baseline S-100B. Retrospectively, the response was correlated with the outcome. In patients with clinical suspicion for brain metastases, MRI or CCT was performed. RESULTS: There was agreement between FDG-PET/CT and CT regarding response to chemotherapy in all patients. There was a clear trend to a longer OS of PET/CT responders (n=10) compared with PET/CT non-responders (n=15; p=0.072) with remarkably better 1-year OS of 80% compared to 40% (p=0.048). There was a significant longer PFS of PET/CT responders compared with PET/CT non-responders (p=0.002). S-100B was normal at baseline in eight of 22 patients where it was available. Chemotherapy response assessment with S-100B failed to show correlation with OS or PFS. Eleven patients developed brain metastases during treatment, first detected by PET/CT in two and by MRI or CCT in nine of 11 patients. Appearance of brain metastases was associated with a poor survival. CONCLUSIONS: 18F-FDG-PET/CT and CT alone are equally suitable for chemotherapy response assessment in melanoma patients and clearly superior to S-100B. PET/CT responders have better early survival, but this is shortlived due to late therapy failure--often with brain recurrence. Additional brain MRI for therapy response assessment in such high-risk patients is mandatory to detect brain metastases missed by PET/CT. |
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Authors:
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Klaus Strobel; Reinhard Dummer; Hans C Steinert; Katrin Baumann Conzett; Karin Schad; Marisol Pérez Lago; Jan D Soyka; P Veit-Haibach; Burkhardt Seifert; V Kalff |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-05-06 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 35 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-23 Completed Date: 2009-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 1786-95 Citation Subset: IM |
Affiliation:
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Division of Nuclear Medicine, Department of Medical Radiology, University Hospital Zurich, Raemistr. 100, 8091, Zurich, Switzerland. klaus.strobel@usz.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antineoplastic Agents / therapeutic use* Brain / pathology*, radiography* Fluorodeoxyglucose F18 / diagnostic use* Humans Magnetic Resonance Imaging / methods* Melanoma* / blood, diagnosis, drug therapy, secondary Middle Aged Nerve Growth Factors / blood* Outcome Assessment (Health Care) / methods Positron-Emission Tomography / methods* Prognosis Radiopharmaceuticals / diagnostic use Reproducibility of Results Retrospective Studies S100 Proteins / blood* Sensitivity and Specificity Subtraction Technique Survival Analysis Survival Rate Tomography, X-Ray Computed / methods* Treatment Outcome Tumor Markers, Biological / blood |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Nerve Growth Factors; 0/Radiopharmaceuticals; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins; 0/Tumor Markers, Biological; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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