Document Detail

Chemotherapy-related secondary leukemias: A role for DNA repair by error-prone non-homologous end joining in topoisomerase II - Induced chromosomal rearrangements.
MedLine Citation:
PMID:  17234368     Owner:  NLM     Status:  MEDLINE    
Chromosome rearrangements are believed to cause the secondary leukemias which constitute frequent complications of antitumor chemotherapy with topoisomerase II-specific drugs. Here we show that inhibition of DNA topoisomerase II in cultured cells stimulates association of components of the non-homologous end joining system with a known breakpoint cluster region of the human AML1 gene, suggesting that errors of DNA repair during NHEJ may be the cause of illegitimate recombination in cells treated with topoisomerase II poisons.
Omar L Kantidze; Sergey V Razin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-14
Journal Detail:
Title:  Gene     Volume:  391     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  76-9     Citation Subset:  IM    
Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology RAS, 34/5 Vavilov Street, 119334 Moscow, Russia.
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MeSH Terms
Antineoplastic Agents, Phytogenic / pharmacology
Chromatin Immunoprecipitation
Chromosome Aberrations / chemically induced*
Chromosome Breakage / drug effects
Core Binding Factor Alpha 2 Subunit / genetics,  metabolism
DNA Breaks, Double-Stranded / drug effects
DNA Repair / genetics,  physiology*
DNA Topoisomerases, Type II / antagonists & inhibitors,  metabolism*
Drug Therapy / adverse effects
Etoposide / pharmacology*
Jurkat Cells
Leukemia / chemically induced,  genetics,  metabolism
Neoplasms / drug therapy
Protein Binding / drug effects
Rad52 DNA Repair and Recombination Protein / metabolism
Recombination, Genetic / drug effects
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Core Binding Factor Alpha 2 Subunit; 0/RAD52 protein, human; 0/RUNX1 protein, human; 0/Rad52 DNA Repair and Recombination Protein; 33419-42-0/Etoposide; EC Topoisomerases, Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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