| Chemotherapy-related secondary leukemias: A role for DNA repair by error-prone non-homologous end joining in topoisomerase II - Induced chromosomal rearrangements. | |
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MedLine Citation:
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PMID: 17234368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chromosome rearrangements are believed to cause the secondary leukemias which constitute frequent complications of antitumor chemotherapy with topoisomerase II-specific drugs. Here we show that inhibition of DNA topoisomerase II in cultured cells stimulates association of components of the non-homologous end joining system with a known breakpoint cluster region of the human AML1 gene, suggesting that errors of DNA repair during NHEJ may be the cause of illegitimate recombination in cells treated with topoisomerase II poisons. |
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Authors:
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Omar L Kantidze; Sergey V Razin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-14 |
Journal Detail:
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Title: Gene Volume: 391 ISSN: 0378-1119 ISO Abbreviation: Gene Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-12 Completed Date: 2007-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706761 Medline TA: Gene Country: Netherlands |
Other Details:
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Languages: eng Pagination: 76-9 Citation Subset: IM |
Affiliation:
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Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology RAS, 34/5 Vavilov Street, 119334 Moscow, Russia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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pharmacology Chromatin Immunoprecipitation Chromosome Aberrations / chemically induced* Chromosome Breakage / drug effects Core Binding Factor Alpha 2 Subunit / genetics, metabolism DNA Breaks, Double-Stranded / drug effects DNA Repair / genetics, physiology* DNA Topoisomerases, Type II / antagonists & inhibitors, metabolism* Drug Therapy / adverse effects Etoposide / pharmacology* Humans Jurkat Cells Leukemia / chemically induced, genetics, metabolism Neoplasms / drug therapy Protein Binding / drug effects Rad52 DNA Repair and Recombination Protein / metabolism Recombination, Genetic / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Core Binding Factor Alpha 2 Subunit; 0/RAD52 protein, human; 0/RUNX1 protein, human; 0/Rad52 DNA Repair and Recombination Protein; 33419-42-0/Etoposide; EC 5.99.1.3/DNA Topoisomerases, Type II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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