Document Detail

Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer.
MedLine Citation:
PMID:  18830610     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Preclinical and clinical evidence support an association between vitamin D deficiency and an increased risk of colorectal cancer. Normal vitamin D status has been linked to favorable health outcomes ranging from decreased risk of osteoporosis to improved cancer mortality. We performed a retrospective study to assess the impact of metastatic disease and chemotherapy treatment on vitamin D status in patients with colorectal cancer residing in Western New York.
MATERIALS AND METHODS: Patients, 315, with colorectal cancer treated in a single institute were assayed for 25-OH vitamin D. The association of age, gender, primary disease site and stage, body mass index, and chemotherapy with vitamin D status was investigated.
RESULTS: Vitamin D deficiency was common among participants with a median 25-OH vitamin D level of 21.3 ng/ml (optimal range 32-100 ng/ml). Primary site of disease and chemotherapy status were associated with very low 25-OH vitamin D levels (< or =15 ng/ml) on multivariate analysis. Patients receiving chemotherapy and patients with a rectal primary were 3.7 and 2.6-fold more likely to have severe vitamin D deficiency on multivariate analysis than nonchemotherapy patients and colon cancer primary patients, respectively.
CONCLUSIONS: Chemotherapy is associated with a significant increase in the risk of severe vitamin D deficiency. Patients with colorectal cancer, especially those receiving chemotherapy, should be considered for aggressive vitamin D replacement strategies.
Marwan G Fakih; Donald L Trump; Candace S Johnson; Lili Tian; Josephia Muindi; Annette Y Sunga
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-02
Journal Detail:
Title:  International journal of colorectal disease     Volume:  24     ISSN:  1432-1262     ISO Abbreviation:  Int J Colorectal Dis     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-05-18     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  8607899     Medline TA:  Int J Colorectal Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Colorectal Neoplasms / complications*,  drug therapy*
Middle Aged
Multivariate Analysis
Vitamin D / metabolism
Vitamin D Deficiency / etiology*
Grant Support
R01 CA067267/CA/NCI NIH HHS; R01 CA067267-13/CA/NCI NIH HHS
Reg. No./Substance:
1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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