Document Detail

Chemotherapy-induced reversible posterior leucoencephalopathy syndrome.
MedLine Citation:
PMID:  20446957     Owner:  NLM     Status:  MEDLINE    
Reversible posterior leucoencephalopathy syndrome is a neurological condition seen in various areas of acute medicine, including the administration of antineoplastic therapies used in haemato-oncology patients. It is a rare complication that has been increasingly recognized. It is characterized by altered mental status, visual disturbance, headache and seizures. Magnetic resonance imaging typically shows vasogenic oedema in the posterior regions of the brain. Although its name suggests reversibility, it may result in an irreversible brain injury without prompt treatment. Therefore, it is vital for treating clinicians to recognize this syndrome. We describe the case of a 55-year-old woman with advanced pancreatic adenocarcinoma, who developed clinical and radiological manifestations consistent with this syndrome as a complication of gemcitabine monotherapy.
C H Han; M P Findlay
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine journal     Volume:  40     ISSN:  1445-5994     ISO Abbreviation:  Intern Med J     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2011-01-18     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  101092952     Medline TA:  Intern Med J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  IM    
Department of Medical Oncology, Auckland City Hospital, Auckland, New Zealand.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Deoxycytidine / adverse effects,  analogs & derivatives*
Middle Aged
Posterior Leukoencephalopathy Syndrome / chemically induced*,  diagnosis*
Reg. No./Substance:
0/Antineoplastic Agents; 951-77-9/Deoxycytidine; B76N6SBZ8R/gemcitabine

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