| Chemotherapy in metastatic, hormone refractory prostatic cancer using chlorambucil in combination with prednisolone versus conjugate, prednimustine (Leo 1031). | |
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MedLine Citation:
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PMID: 7015669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chlorambucil plus prednisolone were administered to 11 patients with metastasis hormone refractory prostatic cancer, and the results were contrasted with a previously reported series of 23 similar patients treated with the chemical conjugate of these two agents, known as prednimustine or Leo 1031. The conjugated form of treatment (Leo 1031) had a limited therapeutic advantage, in that 3 patients experienced shrinkage of an enlarged prostate, 2 of whom also had elevated acid phosphatase levels return to normal and 5 others experienced only subjective improvement. There were, however, more adverse side effects in this group than those noted in patients treated with the combination of agents. Patients treated with the combination of drugs experienced no appreciable tumor shrinkage and none had acid phosphatase return to normal, although some reduction was noted in 8 of 11 patients who had elevated levels initially. Two of the 11 patients were considered stable for twelve months and one other remained ambulatory with mild pain for six months. Thus, to the degree that these studies permit, it is judged that the conjugated agent may have some limited therapeutic advantage not observed when the unconjugated agents were used. |
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Authors:
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S Beckley; L Z Wajsman; N H Slack; G P Murphy |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Urology Volume: 17 ISSN: 0090-4295 ISO Abbreviation: Urology Publication Date: 1981 May |
Date Detail:
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Created Date: 1981-07-20 Completed Date: 1981-07-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 446-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Agents / administration & dosage* Chlorambucil / administration & dosage Clinical Trials as Topic Drug Therapy, Combination Humans Male Middle Aged Neoplasm Metastasis Prednimustine / administration & dosage Prednisolone / administration & dosage Prostatic Neoplasms / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 29069-24-7/Prednimustine; 305-03-3/Chlorambucil; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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