| Chemotherapy of eyelid and peritorbital tumors. | |
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MedLine Citation:
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PMID: 3832525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight patients with nine histologically proven BCC or SCC involving the eyelids and periorbital tissues were treated with systemic and/or local (iontophoresis) chemotherapy using cisplatin and doxorubicin. All patients had either refused surgery, would have required extensive procedures, or had medical problems contraindicating surgery. Systemic chemotherapy induced a CR or PR in eight of nine lesions. No patient has required maintenance chemotherapy and no significant toxic side effects were encountered. The length of follow-up ranges from 2 to 50 months. Iontophoretic therapy with cisplatin was used to treat five small foci of new, recurrent or persistent tumor(s) in three of these patients, and resulted in a partial response in all five lesions. Systemic or local chemotherapy offers an alternative to current standard forms of treatment for BCC and SCC in selected cases. |
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Authors:
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M N Luxenberg; T H Guthrie |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Transactions of the American Ophthalmological Society Volume: 83 ISSN: 0065-9533 ISO Abbreviation: Trans Am Ophthalmol Soc Publication Date: 1985 |
Date Detail:
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Created Date: 1986-05-15 Completed Date: 1986-05-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7506106 Medline TA: Trans Am Ophthalmol Soc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 162-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Basal Cell / drug therapy* Carcinoma, Squamous Cell / drug therapy* Cisplatin / administration & dosage* Doxorubicin / administration & dosage* Eyelid Neoplasms / drug therapy* Facial Neoplasms / drug therapy* Female Follow-Up Studies Humans Iontophoresis Male Middle Aged Orbital Neoplasms / drug therapy*, radiography Time Factors Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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15663-27-1/Cisplatin; 23214-92-8/Doxorubicin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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