Document Detail


Chemotherapy during pregnancy: pharmacokinetics and impact on foetal neurological development.
MedLine Citation:
PMID:  22276398     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Based on an estimated incidence of cancer during pregnancy of 1 per 1000-1500 pregnancies, annualy 3000-5000 new patients can be expected in Europe. The treatment of cancer in pregnant women is a challenge since both the maternal and the foetal well-being need to be considered. This study was initiated to gain better insights into the problems associated with cancer and chemotherapy during pregnancy. A multicentric registration study was set up to evaluate the currently applied treatment modalities for cancer during pregnancy, and the consequences of their use for the pregnancy. Secondly, a preclinical and clinical pharmacological study addressing pharmacokinetics of chemotherapy in pregnant women and transplacental passage of chemotherapy was performed. Thirdly, we investigated the effects of prenatal exposure to chemotherapy on foetal neurological development. We observed an equal distribution of tumour types between pregnant and age matched nonpregnant women. Data on neonatal outcome suggest that exposure to chemotherapy in the 2nd or 3rd trimester of pregnancy does not worsen the outcome. This finding is explained by the fact that chemotherapy is not administered during the period of organogenesis and by the foetal protection by the placental barrier-function. Physiological changes of pregnancy resulted in a decreased plasma drug exposure of chemotherapeutic agents. Before major conclusions can be drawn with regard to the long term foetal outcome and the efficacy of chemotherapy during pregnancy, more patients and a longer follow up period is required. Therefore, this research project is continued and expanded nationally and internationally.
Authors:
K Van Calsteren; F Amant
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Verhandelingen - Koninklijke Academie voor Geneeskunde van België     Volume:  73     ISSN:  0302-6469     ISO Abbreviation:  Verh. K. Acad. Geneeskd. Belg.     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413210     Medline TA:  Verh K Acad Geneeskd Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  105-21     Citation Subset:  IM    
Affiliation:
Department of Obstetrics & Gynecology, University Hospital Gasthuisberg, Herestraat 49--B 3000 Leuven.
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