Document Detail

Chemotherapy during pregnancy and its effects on the fetus--neonatal myelosuppression: two case reports.
MedLine Citation:
PMID:  10685228     Owner:  NLM     Status:  MEDLINE    
Cancer during pregnancy is infrequent. It presents an ethical dilemma--remission may be obtained with chemotherapy, but it has potential harmful effects to the fetus. We report a case of a very low birth weight preterm female infant born to a 21-year-old mother diagnosed with leukemia and given chemotherapy up to 1 week before delivery. In the laboratory, initial findings included severe pancytopenia, and bone marrow aspiration demonstrated complete aplasia. She was given blood product transfusions, erythropoietin, and granulocyte colony stimulating factor. The hematologic derangement was resolved without documented infections. The second case is a preterm male infant whose 30-year-old mother was diagnosed with lymphoma and had received chemotherapy during the third trimester. The infant presented with moderate leukopenia. He had an uneventful course without documented infection. Exposure of the fetus to transplacental chemotherapy must be considered when evaluating therapy options and timing of delivery in hematologic malignancies diagnosed during pregnancy.
L García; M Valcárcel; P J Santiago-Borrero
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  19     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:    1999 Apr-May
Date Detail:
Created Date:  2000-03-09     Completed Date:  2000-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  230-3     Citation Subset:  IM    
Section on Neonatology, University of Puerto Rico School of Medicine, San Juan 00936-5067, USA.
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MeSH Terms
Bone Marrow / drug effects,  embryology
Fetus / drug effects*
Infant, Newborn
Leukemia, Myeloid, Acute / drug therapy*
Lymphoma, B-Cell / drug therapy*
Maternal-Fetal Exchange*
Pregnancy Complications, Neoplastic / drug therapy*
Pregnancy Outcome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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