Document Detail


Chemotherapy during pregnancy: effect of anthracyclines on fetal and maternal cardiac function.
MedLine Citation:
PMID:  22880883     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chemotherapy and especially anthracyclines are associated to cardiotoxicity. To assess this potential risk during pregnancy a clinical case-control trial was conducted. Maternal cardiac function, fetal Doppler and fetal cardiac function were evaluated before and after chemotherapy. Maternal cardiac function was assessed by echocardiography before and after the third cycle of anthracyclines and compared to a control group of 10 non-pregnant women matched for age, type of cancer and anthracycline treatment. Ten fetuses exposed to chemotherapy were compared to 10 control fetuses matched for gestational age and gender. Biometry, amniotic fluid index, fetal Doppler and cardiac function were assessed before and after each cycle of chemotherapy. Hundred and eight fetal ultrasounds scans were performed before and after 36 cycles of chemotherapy. Anthracycline exposure did not result in acute maternal and fetal cardiac dysfunction in this small cohort study.
Authors:
Mina Mhallem Gziri; Frédéric Debiève; Luc DE Catte; Luc Mertens; Catherine Barrea; Kristel VAN Calsteren; Sileny N Han; Liesbeth Heyns; Frédéric Amant
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-10
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium Department of Obstetrics and Gynecology, University Hospitals Saint-Luc, Catholic University of Louvain, Brussels, Belgium Division of Imaging and Cardiovascular Dynamics, University of Leuven, Belgium Division of Cardiology. The Hospital for Sick Children, Toronto, ON, Canada Department of Pediatrics, Unit of Pediatric Cardiology, University Hospitals Saint-Luc, Catholic University of Louvain, Brussels, Belgium.
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