Document Detail


Chemotherapy as an adjuvant to surgery for colorectal cancer.
MedLine Citation:
PMID:  1130879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A combined intraoperative and postoperative adjuvant program of 5 minus Fluorouracil (5 FU) for patients undergoing "curative" resection for adenocarcinoma of the colon and rectum was initiated as a randomized clinical trial in January 1968. Patients at the Medical College of Virginia and the University of Virginia were randomly assigned to an intraluminal 5 FU or intraluminal control (Saline) group and were so treated at the time of surgical resection if findings at operation indicated that all gross neoplastic disease could be resected. Patients with operative findings denoting incurability were eliminated from the study after surgical exploration. Those patients receiving intraluminal 5 FU (30mg/kg) received intravenous 5 FU (10mg/kg) on each of the two first postoperative days and 5 subsequent postoperative courses of oral 5FU (90 mg/kg in each 18 day course) over a one year period. By December 31, 1973 (6 years) 156 patients undergoing "curative" resection were entered into the study. SU therapy with the control or "No Treat" group reveal no significant benefit from this intensive adjuvant course of 5 FU thus far. Continued assessment of these patient groups and their subgroups will be required to develop confidence in these findings but the data thus far suggest no potential benefit from this particular adjuvant program.
Authors:
W Lawrence; J J Terz; S Horsley; M Donaldson; W L Lovett; P W Brown; B W Ruffner; W Regelson
Related Documents :
8219609 - The advantage of primary resection and anastomosis with intraoperative bowel irrigation...
25158949 - Demineralization adjacent to orthodontic brackets after application of conventional and...
9493989 - The bianchi procedure in a patient with jejunal atresia.
15991069 - Progressive increase of bowel wall thickness is a reliable indicator for surgery in pat...
25252839 - The role of agency partnerships in collaborative watershed groups: lessons from the pac...
20526599 - Alvimopan for the management of postoperative ileus after bowel resection: characteriza...
21084399 - Do the effects of testosterone on muscle strength, physical function, body composition,...
18365969 - Preexisting atrial fibrillation as predictor for late-time mortality in patients with e...
25295719 - Effects of postoperative analgesia with the combination of tramadol and lornoxicam on s...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of surgery     Volume:  181     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-07-23     Completed Date:  1975-07-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  616-23     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy,  therapy*
Administration, Oral
Colonic Neoplasms / drug therapy,  surgery,  therapy*
Fluorouracil / administration & dosage,  adverse effects,  therapeutic use*
Humans
Postoperative Care
Postoperative Complications
Prospective Studies
Rectal Neoplasms / drug therapy,  surgery,  therapy*
Recurrence
Sodium Chloride
Chemical
Reg. No./Substance:
51-21-8/Fluorouracil; 7647-14-5/Sodium Chloride
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An analysis of twenty years' experience with operations for carcinoma of the stomach.
Next Document:  Is childhood thyroid cancer a lethal disease?