Document Detail

Chemotherapy as an adjuvant to surgery for colorectal cancer.
MedLine Citation:
PMID:  1130879     Owner:  NLM     Status:  MEDLINE    
A combined intraoperative and postoperative adjuvant program of 5 minus Fluorouracil (5 FU) for patients undergoing "curative" resection for adenocarcinoma of the colon and rectum was initiated as a randomized clinical trial in January 1968. Patients at the Medical College of Virginia and the University of Virginia were randomly assigned to an intraluminal 5 FU or intraluminal control (Saline) group and were so treated at the time of surgical resection if findings at operation indicated that all gross neoplastic disease could be resected. Patients with operative findings denoting incurability were eliminated from the study after surgical exploration. Those patients receiving intraluminal 5 FU (30mg/kg) received intravenous 5 FU (10mg/kg) on each of the two first postoperative days and 5 subsequent postoperative courses of oral 5FU (90 mg/kg in each 18 day course) over a one year period. By December 31, 1973 (6 years) 156 patients undergoing "curative" resection were entered into the study. SU therapy with the control or "No Treat" group reveal no significant benefit from this intensive adjuvant course of 5 FU thus far. Continued assessment of these patient groups and their subgroups will be required to develop confidence in these findings but the data thus far suggest no potential benefit from this particular adjuvant program.
W Lawrence; J J Terz; S Horsley; M Donaldson; W L Lovett; P W Brown; B W Ruffner; W Regelson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of surgery     Volume:  181     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-07-23     Completed Date:  1975-07-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  616-23     Citation Subset:  AIM; IM    
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MeSH Terms
Adenocarcinoma / drug therapy,  therapy*
Administration, Oral
Colonic Neoplasms / drug therapy,  surgery,  therapy*
Fluorouracil / administration & dosage,  adverse effects,  therapeutic use*
Postoperative Care
Postoperative Complications
Prospective Studies
Rectal Neoplasms / drug therapy,  surgery,  therapy*
Sodium Chloride
Reg. No./Substance:
51-21-8/Fluorouracil; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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