Document Detail

Chemotherapy for initial induction failures in childhood acute lymphoblastic leukemia: a Children's Oncology Group Study (POG 8764).
MedLine Citation:
PMID:  23211688     Owner:  NLM     Status:  MEDLINE    
Children with acute lymphocytic leukemia who fail to enter remission have a poor prognosis. In a previous study, 9 of 14 children with induction failure entered remission after teniposide (VM26) plus cytosine arabinoside (Ara-C). We attempted to confirm these results. Twenty children received teniposide (200 mg/m/day IV) for 3 days and cytosine arabinoside (100 mg/m/day continuous IV infusion) for 7 days. There were 3 complete and 3 partial responses. Two additional patients achieved a complete response after a second, shorter course of the same agents. Although VM26 plus Ara-C is an active combination for treatment of acute lymphocytic leukemia induction failure, it does not appear as effective as in the initial report. Better treatments for this problem are needed.
Michael J Joyce; Brad H Pollock; Meenakshi Devidas; George R Buchanan; Bruce Camitta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  35     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-02-21     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-5     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Child, Preschool
Cytarabine / administration & dosage
Hydrocortisone / administration & dosage
Methotrexate / administration & dosage
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Remission Induction
Teniposide / administration & dosage
Treatment Outcome
Young Adult
Grant Support
Reg. No./Substance:
04079A1RDZ/Cytarabine; 957E6438QA/Teniposide; WI4X0X7BPJ/Hydrocortisone; YL5FZ2Y5U1/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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