| Chemotherapy for the biliary tract cancers: moving toward improved survival time. | |
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MedLine Citation:
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PMID: 22328060 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The biliary tract carcinomas rank fifth in incidence among all gastrointestinal tumours. This group of tumours includes both cholangiocarcinoma and gallbladder carcinoma. Although surgery represents the main therapeutic option for these patients, both radiotherapy and chemotherapy could be used in a multidisciplinary approach. Several studies are currently available on the use of chemotherapy, including 5-fluorouracil, mitomycin C, methotrexate, doxorubicin and cisplatin or newer anticancer molecules, such as gemcitabine, capecitabine, oxaliplatin and irinotecan. However, the small sample size of most of these studies prevents generalization. DISCUSSION: We reviewed the available data on both chemotherapy and targeted therapies for biliary carcinoma. By using conventional chemotherapy, a response rate ranging from 10% to 40% has been reported. Although encouraging data emerged with the use of targeted therapies, further efforts are needed to improve treatment options for patients with biliary tract cancer. |
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Authors:
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Adriana Romiti; Chiara D'Antonio; Angelo Zullo; Ida Sarcina; Roberta Di Rocco; Viola Barucca; Valeria Durante; Paolo Marchetti |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of gastrointestinal cancer Volume: 43 ISSN: 1941-6636 ISO Abbreviation: J Gastrointest Cancer Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-23 Completed Date: 2013-02-05 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101479627 Medline TA: J Gastrointest Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 396-404 Citation Subset: IM |
Affiliation:
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Department of Oncology, Sant'Andrea Hospital, La Sapienza University, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use* Biliary Tract Neoplasms / drug therapy*, mortality* Humans Prognosis Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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