Document Detail


Chemotaxis and activation of particle-challenged human monocytes in response to monocyte migration inhibitory factor and C-C chemokines.
MedLine Citation:
PMID:  10398027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines that regulate monocyte migration were found in membrane tissue surrounding loosened prosthetic implants. Monocyte migration inhibition factor (MIF) is able to inhibit macrophage migration. Monocyte chemoattractant protein (MCP) and macrophage inflammatory protein (MIP) are potent macrophage chemoattractants. These cytokines may be expressed as part of the foreign body response to prosthetic particulate debris. Chemotaxis analysis and macrophage activation experiments were performed to determine the effects of MIF, MCP-1, and MIP-1alpha on macrophage migration and activation in vitro. We demonstrated that MIF had its maximal migration inhibitory effect for unchallenged and particle challenged macrophages at 1 ng/mL. MCP-1 and MIP-1alpha stimulated macrophage chemotaxis maximally at 1 to 10 ng/mL. Dose-response studies with MIF, MCP-1, and MIP-1alpha demonstrated that these cytokines did not modulate activation of unchallenged or particle challenged macrophages as evaluated by IL-6 and TNF-alpha release. However, these cytokines do not appear to affect macrophage release of proinflammatory mediators in vitro.
Authors:
M Lind; M C Trindade; Y Nakashima; D J Schurman; S B Goodman; L Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research     Volume:  48     ISSN:  0021-9304     ISO Abbreviation:  J. Biomed. Mater. Res.     Publication Date:  1999  
Date Detail:
Created Date:  2000-05-02     Completed Date:  2000-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0112726     Medline TA:  J Biomed Mater Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  IM    
Copyright Information:
Copyright 1999 John Wiley & Sons, Inc.
Affiliation:
Orthopedic Research Laboratory, Stanford University School of Medicine, Stanford, California, USA. martinlind@dadlnet.dk
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials*
Cells, Cultured
Chemokines, CC / pharmacology*
Chemotaxis, Leukocyte / drug effects*
Humans
Macrophage Activation / drug effects
Macrophage Migration-Inhibitory Factors / pharmacology*
Macrophages / drug effects,  pathology
Monocytes / drug effects*,  pathology*
Particle Size
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Chemokines, CC; 0/Macrophage Migration-Inhibitory Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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