Document Detail

Chemosensory function, food preferences and appetite in human liver disease.
MedLine Citation:
PMID:  8373143     Owner:  NLM     Status:  MEDLINE    
We evaluated chemosensory function, food preferences, and appetite in 88 patients with liver disease including those with hepatitis, cirrhosis, primary biliary cirrhosis, and sclerosing cholangitis. Reported chemosensory disturbances were common in the patients with liver disease: over 40% reported recent taste changes, and 27% reported recent changes in smell, compared to only 6% of healthy, age- and gender-matched controls with no history of marked chemosensory malfunction. Compared to controls, a greater proportion of liver patients reported food cravings (47 vs. 17%) and food aversions (33 vs. 16%). Foods with a predominantly bitter taste were specifically less preferred in patients with liver disease compared to healthy controls. Patients were also more likely to report poor to fair appetite than controls (37 vs. 5%). Groups of patients with different types of liver pathology showed varying patterns of food preferences, suggesting that dietary recommendations to liver patients might be tailored to the altered preferences associated with a particular type of hepatic dysfunction.
R O Deems; M I Friedman; L S Friedman; S J Munoz; W C Maddrey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Appetite     Volume:  20     ISSN:  0195-6663     ISO Abbreviation:  Appetite     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-08     Completed Date:  1993-10-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-16     Citation Subset:  IM    
Monell Chemical Senses Center, Philadelphia, PA 19104.
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MeSH Terms
Chemoreceptor Cells / physiology*
Cholangitis / physiopathology
Food Preferences*
Hepatitis / physiopathology
Liver Cirrhosis / physiopathology
Liver Cirrhosis, Biliary / physiopathology
Liver Diseases / physiopathology*
Middle Aged
Smell / physiology
Taste / physiology
Grant Support

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