Document Detail


Chemoselective Oxime Reactions in Proteins and Peptides by Using an Optimized Oxime Strategy: The Demise of Levulinic Acid.
MedLine Citation:
PMID:  24151209     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Selecting the right partner faster: In protein chemoselective conjugation, the use of levulinic acid for ketone introduction leads to slow oxime formation and poor yield because of internal cyclization, especially at low concentrations. A mechanism for cyclization is proposed and alternative keto-acids have been tested. These showed faster formation of oximes without side products.
Authors:
Stijn M Agten; Dennis Suylen; Hans Ippel; Maria Kokozidou; Guido Tans; Pieter van de Vijver; Rory R Koenen; Tilman M Hackeng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-22
Journal Detail:
Title:  Chembiochem : a European journal of chemical biology     Volume:  -     ISSN:  1439-7633     ISO Abbreviation:  Chembiochem     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100937360     Medline TA:  Chembiochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Biochemistry, Cardiovascular research institute Maastricht (CARIM), Maastricht University, P. O. Box 616, 6200 MD Maastricht (The Netherlands). s.agten@maastrichtuniversity.nl.
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