| Chemoreflex activity increases prostaglandin endoperoxide synthase mRNA expression in the late-gestation fetal sheep brain. | |
| | |
MedLine Citation:
|
PMID: 21846688 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Fetal sheep defend blood pressure, blood volume, and blood gases using baro- and chemoreflexes that influence autonomic and neuroendocrine responses. The local generation of prostanoids within the fetal brain is also an important component in activating hormone responses to these stimuli, but the relationship between the reflexes and prostanoid biosynthesis is unclear. The present study was performed to test the hypothesis that the abundances of prostaglandin biosynthetic enzymes in the fetal brain are dependent upon the activity of the baro- and chemoreflex pathways. We subjected chronically catheterized fetal sheep in late gestation to a 10-minute period of brachiocephalic occlusion (BCO), a stimulus that provokes brisk cardiovascular and neuroendocrine responses. We compared the central nervous system abundance of prostaglandin endoperoxide synthases 1 and 2 (PGHS-1 and PGHS-2) after BCO to (1) fetal sheep that had been subjected to BCO after chronic sinoaortic denervation plus bilateral vagotomy and (2) fetal sheep in which the N-methyl d-aspartate (NMDA) receptor antagonist, ketamine, had been administered prior to BCO. Abundances of messenger RNA (mRNA) for PGHS-1 and of mRNA and protein for PGHS-2 in fetal hippocampus were reduced significantly by either prior denervation or ketamine administration. Prostaglandin endoperoxide synthases 1 and 2 mRNA in pituitary were decreased and increased, respectively, by ketamine pretreatment. The results of this study are consistent with the conclusion that the expression of PGHS-1 and -2 in fetal hippocampus and pituitary are influenced by the baro- and/or chemoreflex pathways within the fetal brain in late gestation. |
| | |
Authors:
|
Melanie J P Fraites; Charles E Wood |
Related Documents
:
|
21315338 - Rupture of endometriotic ovarian cyst causes acute hemoperitoneum in twin pregnancy. 10861718 - Norman-roberts syndrome: prenatal diagnosis and autopsy findings. 2675598 - Comparison of six different ultrasonographic methods for predicting lethal fetal pulmon... 11264098 - The anterior iliac separation: alternative index for pelvic morphometry in fetuses with... 15132198 - Gender in the consulting room. 7944318 - Intraoperative molar pregnancy crisis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 18 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 824-31 Citation Subset: IM |
Affiliation:
|
1Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Continuous monitoring of pop hole usage by commercially housed free-range hens throughout the produc...
Next Document: AMG 479, a Novel IGF-1-R Antibody, Inhibits Endometrial Cancer Cell Proliferation Through Disruption...