| Chemoradiation interactions under reduced oxygen conditions: Cellular characteristics of an in vitro model. | |
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MedLine Citation:
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PMID: 19540039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoxic tumour regions often contain viable cells that are more resistant to chemotherapy and/or radiotherapy, making it of key importance to analyse new combination treatments under both normoxic and hypoxic conditions. In this study, the impact of moderate hypoxia and anoxia on cellular characteristics was investigated in isogenic A549 cells differing in p53 status. VEGF expression, doubling time, cell cycle distribution, induction of apoptosis and p53 protein expression were evaluated. Radiation survival curves yielded an oxygen enhancement ratio of 1.16-1.67. In conclusion, an in vitro hypoxia model that will be highly useful to analyse chemoradiation interactions is presented. |
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Authors:
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An Wouters; Bea Pauwels; Hilde A J Lambrechts; Greet G O Pattyn; Johan Ides; Marc Baay; Paul Meijnders; Sylvia Dewilde; Jan B Vermorken; Filip Lardon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-18 |
Journal Detail:
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Title: Cancer letters Volume: 286 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-17 Completed Date: 2010-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 180-8 Citation Subset: IM |
Affiliation:
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Laboratory of Cancer Research and Clinical Oncology, Department of Medical Oncology, University of Antwerp, 2610 Wilrijk, Belgium. An.Wouters@ua.ac.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects*,
radiation effects Blotting, Western Cell Cycle / drug effects, radiation effects Cell Hypoxia Cell Line, Tumor Cell Proliferation / drug effects, radiation effects Cell Survival / drug effects, radiation effects Humans Oxygen / metabolism, pharmacology* Reverse Transcriptase Polymerase Chain Reaction Time Factors Tumor Suppressor Protein p53 / genetics, metabolism* Vascular Endothelial Growth Factor A / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53; 0/Vascular Endothelial Growth Factor A; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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