| Chemoprotection against cyclophosphamide-induced urotoxicity: ribose-cysteine. | |
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MedLine Citation:
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PMID: 8017837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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2(R,S)-D-ribo-(1',2',3',4'-tetrahydroxybutyl) thiazolidine-4(R)-carboxylic acid (RibCys) is a prodrug of L-cysteine, which can facilitate the detoxication of numerous substances either directly or by providing the limiting amino acid for the biosynthesis of glutathione (GSH). RibCys was studied for its chemoprotective activity against the potent urotoxicity associated with the common anticancer agent, cyclophosphamide (CTX). In Swiss-Webster mice, RibCys given between 30 min before the toxin to 30 min after, either in a single or a split dose, exhibited powerful ability to protect against CTX-induced bladder inflammation and GSH depletion. |
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Authors:
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J C Roberts; D J Francetic |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Anticancer research Volume: 14 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 1994 Mar-Apr |
Date Detail:
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Created Date: 1994-07-25 Completed Date: 1994-07-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: GREECE |
Other Details:
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Languages: eng Pagination: 383-7 Citation Subset: IM |
Affiliation:
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Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Cyclophosphamide / pharmacokinetics, toxicity* Dose-Response Relationship, Drug Glutathione / metabolism Liver / drug effects, metabolism Male Metabolic Detoxication, Drug Mice Organ Size / drug effects Prodrugs / metabolism, pharmacology* Thiazoles / metabolism, pharmacology* Thiazolidines Urinary Bladder / drug effects*, metabolism, pathology |
| Grant Support | |
ID/Acronym/Agency:
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5P30 CA42401/CA/NCI NIH HHS; R29 GM44785/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Prodrugs; 0/Thiazoles; 0/Thiazolidines; 17087-36-4/2-(1',2',3',4'-tetrahydroxybutyl)thiazolidine-4-carboxylic acid; 50-18-0/Cyclophosphamide; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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