| Chemopreventive effects of mate against mouse mammary and colon carcinogenesis. | |
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MedLine Citation:
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PMID: 20071474 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The present study evaluated the chemopreventive potential of mate tea-like intake on mammary and colon carcinogenesis initiated by 7,12-dimethylbenz(a)antracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Swiss mice. After the initiation period, the animals received basal diet and organic mate tea-like, conventional mate tea-like, or green tea (positive control) at 2.0% as the drinking fluid during 15 weeks. At week 20, colon and mammary gland were analyzed for preneoplastic and neoplastic lesions development. Colon and mammary gland complexes were processed for cell proliferation analysis, estimated by proliferating cell nuclear antigen labeling index (PCNA-LI%). Specially, organic mate tea-like reduced the values of PCNA-LI% in colonic crypts (p < .003) and in mammary glands (p < .05) in DMBA/DMH-initiated groups. A lower incidence of aberrant crypt foci (ACF) in colon (p = .03) and of hyperplastic and neoplastic lesions in mammary gland (p < .05 and p < .02, respectively) was observed in DMBA/DMH-initiated groups treated with organic mate tea-like. These results suggest that post-initiation treatment with organic mate tea-like inhibited the development of colon and mammary carcinogenesis in a two-step medium-term mouse carcinogenesis model. |
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Authors:
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Joyce R Zapaterini; Lucas T Bidinotto; Maria A M Rodriguues; Luís F Barbisan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-1-13 |
Journal Detail:
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Title: Human & experimental toxicology Volume: - ISSN: 1477-0903 ISO Abbreviation: - Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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UNESP São Paulo State University, Institute of Biosciences, Department of Morphology, Botucatu, SP, 18618-000, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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