Document Detail

Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guaraná, on mouse hepatocarcinogenesis.
MedLine Citation:
PMID:  15885883     Owner:  NLM     Status:  MEDLINE    
Guaraná (Paullinia cupana) is originally from Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guaraná presented inhibitory effects on DEN hepatocarcinogenesis in mice.
Heidge Fukumasu; Tereza Cristina da Silva; José Luis Avanzo; Cyntia Esteves de Lima; Ivone Isabel Mackowiak; André Atroch; Helenice de Souza Spinosa; Fernando Salvador Moreno; Maria Lucia Zaidan Dagli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  233     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-13     Completed Date:  2006-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  158-64     Citation Subset:  IM    
Laboratory of Experimental Oncology, Department of Pathology, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr Orlando Marques de Paiva, 87. CEP 05508-900 São Paulo, SP, Brazil.
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MeSH Terms
Caffeine / pharmacology
Liver Neoplasms, Experimental / pathology,  prevention & control*
Mice, Inbred BALB C
Plant Extracts / therapeutic use*
Precancerous Conditions / prevention & control
Proliferating Cell Nuclear Antigen / analysis
Reg. No./Substance:
0/Plant Extracts; 0/Proliferating Cell Nuclear Antigen; 58-08-2/Caffeine

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