| Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. | |
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MedLine Citation:
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PMID: 22231745 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant and intestinal antinflammatory) and mechanisms (inhibition of endocannabinoid enzymatic degradation) potentially beneficial for colon carcinogenesis. Thus, we investigated its possible chemopreventive effect in the model of colon cancer induced by azoxymethane (AOM) in mice. AOM treatment was associated with aberrant crypt foci (ACF, preneoplastic lesions), polyps, and tumour formation, up-regulation of phospho-Akt, iNOS and COX-2 and down-regulation of caspase-3. Cannabidiol-reduced ACF, polyps and tumours and counteracted AOM-induced phospho-Akt and caspase-3 changes. In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPARγ-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms. |
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Authors:
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Gabriella Aviello; Barbara Romano; Francesca Borrelli; Raffaele Capasso; Laura Gallo; Fabiana Piscitelli; Vincenzo Di Marzo; Angelo A Izzo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: Journal of molecular medicine (Berlin, Germany) Volume: - ISSN: 1432-1440 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504370 Medline TA: J Mol Med (Berl) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Experimental Pharmacology, Endocannabinoid Research Group, University of Naples Federico II, Naples, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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