| Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. | |
| | |
MedLine Citation:
|
PMID: 20848615 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Scope: Curcumin is a polyphenol with a variety of pharmacologic effects. We evaluate the effect of dietary curcumin on the severity of repeated colitis-associated colorectal cancer. Methods and results: Six-week-old C57BL/6 mice were randomized into two dietary groups: standard diet and curcumin at 0.6% diet. The mice were exposed to 15 cycles of 0.7% dextran sodium sulphate for 1 week followed by distilled water for 10 days. After curcumin diet, the disease activity index presented a statistical reduction in the last cycles, macroscopic tumors were not seen and the microscopic study showed minor neoplasic lesions with respect to standard diet-group. β-Catenin translocation to the cytoplasm and/or nucleus was observed in the tumor tissue, but this translocation and its intensity were significantly minor in the curcumin diet-DSS animals. Cytokines as tumor necrosis factor-α and IFN-γ were significantly diminished in DSS-animals fed with curcumin. Conversely, non-modification of p53 expression was observed and cyclo-oxygenase-2 and inducible nitric oxide synthase were significantly reduced in the curcumin diet-DSS group. Conclusion: We demonstrate the protective/preventive effect of curcumin in the progression of colorectal cancer associated to colitis, which was correlated with a lowered immunoreactivity of ß-catenin, a non-modification of p53 expression, a reduction of proinflammatory cytokine levels and a decrease of inflammatory protein overexpression. |
| | |
Authors:
|
Isabel Villegas; Susana Sánchez-Fidalgo; Catalina Alarcón de la Lastra |
Related Documents
:
|
18551895 - Tissue levels of arsenicals and skin tumor response following administration of monomet... 1600605 - Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related co... 21830045 - Seed predation by bonobos (pan paniscus) at kokolopori, democratic republic of the congo. 9619875 - Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinog... 12099685 - Effects of nutrition on the cell survival and gene expression of transplanted fat tissu... 991535 - Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism... |
Publication Detail:
|
Type: Journal Article Date: 2010-09-16 |
Journal Detail:
|
Title: Molecular nutrition & food research Volume: 55 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
|
Languages: eng Pagination: 259-67 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Department of Pharmacology, School of Pharmacy, University of Seville, Seville, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neurogenesis in subclasses of vomeronasal sensory neurons in adult mice.
Next Document: Multimethod study of distress tolerance and PTSD symptom severity in a trauma-exposed community samp...