Document Detail


Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma.
MedLine Citation:
PMID:  20307637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ETHNOPHARMACOLOGICAL RELEVANCE: Butea monosperma (Lam.) (Fabaceae) popularly known as 'flame of the forest' has been widely used in the traditional Indian medical system of 'Ayurveda' for the treatment of a variety of ailments including liver disorders. AIM OF THE STUDY: To evaluate the antioxidative, anti-inflammatory, hepatoprotective and anti-cancer activities of the aqueous extract of Butea monosperma flowers. MATERIALS AND METHODS: Dried flowers of Butea monosperma were extracted with water. The extract was tested for its anti-proliferative, pro-apoptotic and anti-carcinogenic effects in hepatoma cell lines. The chemopreventive and anti-angiogenic effects of the extract were evaluated by its daily oral administration in a HBV-related X15-myc mouse model of hepatocellular carcinoma (HCC). RESULTS: Treatment with the aqueous extract inhibited cell proliferation and accumulation of cells in G1 phase. This was accompanied by a marked reduction in the levels of activated Erk1/2 and SAPK/JNK and induction of apoptotic cell death. Oral administration of the extract in transgenic mice conferred hepatoprotection as is evident from normal serum ALT levels and improved liver histopathology and lowered serum VEGF level. CONCLUSIONS: The ability of aqueous extract of Butea monosperma flowers to impose growth arrest and trigger pro-apoptotic death in cell culture strongly correlated with its strong chemopreventive effect in vivo when given orally.
Authors:
Tenzin Choedon; Surendra Kumar Shukla; Vijay Kumar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-20
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  129     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  208-13     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Alanine Transaminase / blood
Animals
Anti-Inflammatory Agents / pharmacology,  therapeutic use
Antineoplastic Agents, Phytogenic / pharmacology,  therapeutic use*
Antioxidants / pharmacology,  therapeutic use
Apoptosis / drug effects
Butea* / chemistry
Carcinoma, Hepatocellular / drug therapy*,  metabolism,  pathology
Cell Death / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects*
Flowers
Humans
Liver / drug effects,  metabolism,  pathology
Liver Neoplasms / drug therapy*,  metabolism,  pathology
Mice
Mice, Transgenic
Mitogen-Activated Protein Kinases / metabolism
Phytotherapy*
Plant Extracts / pharmacology,  therapeutic use*
Vascular Endothelial Growth Factor A / blood
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antineoplastic Agents, Phytogenic; 0/Antioxidants; 0/Plant Extracts; 0/Vascular Endothelial Growth Factor A; EC 2.6.1.2/Alanine Transaminase; EC 2.7.11.24/Mitogen-Activated Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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