Document Detail

Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells.
MedLine Citation:
PMID:  11163107     Owner:  NLM     Status:  MEDLINE    
Resveratrol, a natural product derived from grapes, has been shown to prevent carcinogenesis in murine models. We report here that resveratrol induces antiproliferation and arrests the S phase in human histiocytic lymphoma U937 cells. Resveratrol induces arrest in the S phase at low concentrations (30-60 microM), but high concentrations do not induce S phase accumulation in U937 cells. Removal of resveratrol from the culture medium stimulates U937 cells to reenter the cell cycle synchronously, as judged by the expression patterns of cyclin E, A and by fluorescent activated cell sorting analysis. These data demonstrate that resveratrol causes S phase arrest and reversible cell cycle arrest. Thus, resveratrol provides an important new cell cycle blocker as well as a cancer chemopreventive agent.
J W Park; Y J Choi; M A Jang; Y S Lee; D Y Jun; S I Suh; W K Baek; M H Suh; I N Jin; T K Kwon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  163     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-08     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM    
Department of Immunology, School of Medicine, Keimyung University, 194 Dong San-Dong Jung-Gu, Taegu 700-712, South Korea.
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MeSH Terms
Antineoplastic Agents, Phytogenic / pharmacology*
Blotting, Western
Cell Count
Cell Cycle / drug effects
Cell Cycle Proteins / drug effects,  metabolism
Cell Division / drug effects
Dose-Response Relationship, Drug
Flow Cytometry
G2 Phase / drug effects*
Rosales / chemistry*
S Phase / drug effects*
Stilbenes / pharmacology*
Time Factors
U937 Cells
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Cell Cycle Proteins; 0/Stilbenes; Q369O8926L/resveratrol

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