Document Detail

The Chemopreventive Capacity of Quercetin to Induce Programmed Cell Death in Hepatocarcinogenesis.
MedLine Citation:
PMID:  23197198     Owner:  NLM     Status:  Publisher    
In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN-induced lipid peroxidation as well as activation of caspase 9 and increased caspase 3, as determined by increased expression of cleaved caspase 3 and 9, but not cleaved caspase 8 and increased fragmentation of Poly (ADP-ribose) polymerase (PARP) inducing apoptosis of presumed genetically injured cells, when quercetin was administered before the initiation agent.
Verónica Rocío Vásquez-Garzón; José Roberto Macias-Pérez; Mónica Noemí Jiménez-García; Vanessa Villegas; Samia Fattel-Fazenta; Saúl Villa-Treviño
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-29
Journal Detail:
Title:  Toxicologic pathology     Volume:  -     ISSN:  1533-1601     ISO Abbreviation:  Toxicol Pathol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del IPN, México D.F., México.
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