| Chemoprevention of prostate cancer with lycopene in the TRAMP model. | |
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MedLine Citation:
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PMID: 20687227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dietary lycopene combined with other constituents from whole tomatoes was previously found to have greater chemopreventive effects against prostate cancer as compared to pure lycopene provided in a beadlet formulation. We hypothesized that tomato paste would have greater chemopreventive effects in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice relative to equivalent lycopene doses provided from lycopene beadlets. METHODS: Fifty-nine TRAMP mice were randomized to a control diet or to diets providing 28 mg lycopene per kg diet from tomato paste (TP) or from lycopene beadlet (LB), and sacrificed at 20 weeks. Prostate histopathology, prostate weight and serum levels of IGF-I and IGF binding protein-3 were evaluated. RESULTS: The incidence of prostate cancer was significantly decreased in the LB group relative to the control group (60% vs. 95%, respectively, P = 0.0197) whereas the difference between the TP and control groups was not statistically significant (80% vs. 95%, P = 0.34). There was no difference in prostate weights between the groups. Total lycopene levels in the serum and prostate tissue were similarly elevated in the LB and TP groups relative to the control group. The ratio of 5-cis-lycopene to trans-lycopene in the serum was significantly greater in the LB group relative to the TP group (P = 0.0001). Oxidative DNA damage was significantly reduced in the livers of mice fed LB and TP diets relative to the control group. CONCLUSIONS: This preclinical trial suggests significant chemopreventive activity with a lycopene beadlet-enriched diet. The chemopreventive effects of lycopene from beadlets versus whole tomato products requires further testing in preclinical and clinical models of prostate cancer. |
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Authors:
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Ramdev Konijeti; Susanne Henning; Aune Moro; Ahmed Sheikh; David Elashoff; Ari Shapiro; Melvin Ku; Jonathan W Said; David Heber; Pinchas Cohen; William J Aronson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Prostate Volume: 70 ISSN: 1097-0045 ISO Abbreviation: Prostate Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-09-23 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 8101368 Medline TA: Prostate Country: United States |
Other Details:
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Languages: eng Pagination: 1547-54 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed* Animals Anticarcinogenic Agents / therapeutic use* Carotenoids / administration & dosage, blood, therapeutic use* DNA Damage Diet Disease Models, Animal Humans Insulin-Like Growth Factor Binding Protein 3 / blood Insulin-Like Growth Factor I / metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Organ Size Prostate / anatomy & histology Prostatic Neoplasms / prevention & control* Random Allocation Vitamin E / administration & dosage, blood, therapeutic use Vitamins / administration & dosage, therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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5P50CA092131-07/CA/NCI NIH HHS; 5R01CA100938-05/CA/NCI NIH HHS; P30DK063491/DK/NIDDK NIH HHS; R01 CA100938-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Vitamins; 1406-18-4/Vitamin E; 36-88-4/Carotenoids; 502-65-8/lycopene; 67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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