Document Detail

Chemoprevention of prostate cancer by diet-derived antioxidant agents and hormonal manipulation (Review).
MedLine Citation:
PMID:  12469179     Owner:  NLM     Status:  MEDLINE    
Cancer of the prostate is the most commonly diagnosed solid malignancy and the second leading cause of cancer-related death in men living in developed countries. With an ageing population, the number of men living with early stages of prostate cancer is expected to increase. There is an increasing need to prevent the onset of cancer or delay the progression of carcinogenesis in this organ. Chemoprevention is the administration of pharmacological agents to prevent, delay or reverse carcinogenesis. An example is the reversal of high grade intraepithelial neoplasia by hormonal manipulation using anti-oestrogens in breast carcinogenesis or anti-androgens in prostate carcinogenesis. Epidemiological data showing ethnic and geographic variations in the incidence of, and mortality from, prostate cancer have suggested that the consumption of certain dietary factors, particularly anti-oxidants, may be protective. These factors include the vitamins D and E, soy, lycopene and selenium. The administration of 5-alpha reductase inhibitors to patients with benign prostatic hyperplasia may also constitute a potentially chemopreventive intervention. The efficacy of chemopreventive agents needs to be investigated in randomised, placebo-controlled trials in suitable cohorts of high-risk individuals. In parallel, reliable assays of potential biomarkers of the efficacy of intervention need to be developed and validated rigorously.
S K Pathak; R A Sharma; J K Mellon
Related Documents :
23715579 - Resolution of clostridium difficile-associated diarrhea in patients with cancer treated...
25216549 - Topbp1 and claspin contribute to the radioresistance of lung cancer brain metastases.
23060049 - Factors influencing the number of pelvic and para-aortic lymph nodes removed in surgica...
19956119 - Editorial: colorectal cancer and statins: reflections from the end of the road.
15098969 - Topical retinoid and antibiotic combination therapy for acne management.
17234229 - Tea and cancer prevention: molecular mechanisms and human relevance.
16702579 - The role of prevention in oncology practice: results from a 2004 survey of american soc...
9213309 - Alternatives to chemotherapy and radiotherapy as adjuvant treatment for lung cancer.
20037839 - Loss of tissue expression of interleukin-10 promotes the disease progression of colorec...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International journal of oncology     Volume:  22     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-06     Completed Date:  2003-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  5-13     Citation Subset:  IM    
Cancer Biomarkers and Prevention Group, Department of Oncology, University of Leicester, Leicester, LE2 7LX, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anticarcinogenic Agents / pharmacology,  therapeutic use*
Antioxidants / pharmacology,  therapeutic use*
Carotenoids / therapeutic use
Dietary Fats / administration & dosage
Enzyme Inhibitors / therapeutic use
Prostatic Neoplasms / prevention & control*
Testosterone 5-alpha-Reductase / antagonists & inhibitors
Vitamin D / therapeutic use
Vitamin E / therapeutic use
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Antioxidants; 0/Dietary Fats; 0/Enzyme Inhibitors; 1406-16-2/Vitamin D; 1406-18-4/Vitamin E; 36-88-4/Carotenoids; 502-65-8/lycopene; EC 5-alpha-Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Enkephalin degradating enzymes in pheochromocytoma patients.
Next Document:  Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review).