Document Detail


Chemoprevention of prostate cancer by diet-derived antioxidant agents and hormonal manipulation (Review).
MedLine Citation:
PMID:  12469179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cancer of the prostate is the most commonly diagnosed solid malignancy and the second leading cause of cancer-related death in men living in developed countries. With an ageing population, the number of men living with early stages of prostate cancer is expected to increase. There is an increasing need to prevent the onset of cancer or delay the progression of carcinogenesis in this organ. Chemoprevention is the administration of pharmacological agents to prevent, delay or reverse carcinogenesis. An example is the reversal of high grade intraepithelial neoplasia by hormonal manipulation using anti-oestrogens in breast carcinogenesis or anti-androgens in prostate carcinogenesis. Epidemiological data showing ethnic and geographic variations in the incidence of, and mortality from, prostate cancer have suggested that the consumption of certain dietary factors, particularly anti-oxidants, may be protective. These factors include the vitamins D and E, soy, lycopene and selenium. The administration of 5-alpha reductase inhibitors to patients with benign prostatic hyperplasia may also constitute a potentially chemopreventive intervention. The efficacy of chemopreventive agents needs to be investigated in randomised, placebo-controlled trials in suitable cohorts of high-risk individuals. In parallel, reliable assays of potential biomarkers of the efficacy of intervention need to be developed and validated rigorously.
Authors:
S K Pathak; R A Sharma; J K Mellon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International journal of oncology     Volume:  22     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-06     Completed Date:  2003-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  5-13     Citation Subset:  IM    
Affiliation:
Cancer Biomarkers and Prevention Group, Department of Oncology, University of Leicester, Leicester, LE2 7LX, UK.
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MeSH Terms
Descriptor/Qualifier:
Anticarcinogenic Agents / pharmacology,  therapeutic use*
Antioxidants / pharmacology,  therapeutic use*
Carotenoids / therapeutic use
Chemoprevention
Dietary Fats / administration & dosage
Enzyme Inhibitors / therapeutic use
Humans
Male
Prostatic Neoplasms / prevention & control*
Testosterone 5-alpha-Reductase / antagonists & inhibitors
Vitamin D / therapeutic use
Vitamin E / therapeutic use
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Antioxidants; 0/Dietary Fats; 0/Enzyme Inhibitors; 1406-16-2/Vitamin D; 1406-18-4/Vitamin E; 36-88-4/Carotenoids; 502-65-8/lycopene; EC 1.3.99.5/Testosterone 5-alpha-Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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