Document Detail


Chemoprevention of oral and esophageal cancer in Uzbekistan, Union of Soviet Socialist Republics.
MedLine Citation:
PMID:  2939349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The results of a survey of a population with a high risk of oral and esophageal cancer and the outline of a chemoprevention scheme for persons found to have a precancerous condition of the mouth and esophagus are presented. Of a total of 1,569 men examined, 11% had preleukoplakia and leukoplakia of the mouth, and 60% of the 1,344 men in whom esophagogastroscopy was performed had chronic esophagitis. The relative risk of oral leukoplakia was highest (11.5) among men who smoke and use nass quid. The relative risk was also elevated for persons who only use nass quid (5.6) or who only smoke cigarettes (7.8). Nass use had no effect on the risk of esophagitis. A slight elevation of risk (1.9) of esophagitis was observed for current smokers and drinkers. Of the men from whom blood was drawn for analysis, 4%, 66%, and 86% had low levels of retinol, carotene, and riboflavin, respectively. The high prevalence of oral and esophageal precancerous conditions and low blood levels of riboflavin, carotene, and vitamin A observed in the surveyed population, as well as the existing evidence on the possible protective effect of these nutrients in carcinogenesis, provide an opportunity and a justification for the chemopreventive trial, with the regression of observed precancerous lesions as the end point of the study.
Authors:
D G Zaridze; J P Kuvshinov; E Matiakin; B I Polakov; P Boyle; M Blettner
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  National Cancer Institute monograph     Volume:  69     ISSN:  0083-1921     ISO Abbreviation:  Natl Cancer Inst Monogr     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-06-03     Completed Date:  1986-06-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0216026     Medline TA:  Natl Cancer Inst Monogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Alcohol Drinking
Carotenoids / blood
Clinical Trials as Topic
Esophageal Neoplasms / etiology,  prevention & control*
Ethnic Groups
Humans
Male
Mastication
Middle Aged
Mouth Neoplasms / etiology,  prevention & control*
Precancerous Conditions / drug therapy
Riboflavin / blood
Risk
Smoking
Uzbekistan
Vitamin A / blood
Chemical
Reg. No./Substance:
11103-57-4/Vitamin A; 36-88-4/Carotenoids; 83-88-5/Riboflavin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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