| Chemoprevention of intestinal polyps in ApcMin/+ mice fed western or balanced diets by drinking Annurca apple polyphenol extract. | |
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MedLine Citation:
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PMID: 21383028 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The western diet (WD) is associated with a higher incidence of colorectal cancer (CRC) than the Mediterranean diet. Polyphenols extracted from Annurca apple (APE) showed chemopreventive properties in CRC cells. A multifactorial, four-arm study using wild-type (wt) and Apc(Min/+) mice was carried out to evaluate the effect on polyp number and growth of APE treatment (60 μM) ad libitum in drinking water combined with a WD or a Balanced Diet (BD) for 12 weeks. Compared to APE treatment, we found a significant drop in body weight (P < 0.0001), severe rectal bleeding (P = 0.0076), presence of extra-intestinal tumors and poorer activity status (P = 0.0034) in water-drinking Apc(Min/+) mice, more remarkably in the WD arm. In the BD and WD groups, APE reduced polyp number (35% and 42% respectively, P < 0.001) and growth (60% and 52% respectively, P < 0.0001) in both colon and small intestine. Increased antioxidant activity was found in wt animals fed both diets and in Apc(Min/+) mice fed WD and drinking APE. Reduced lipid peroxidation was found in Apc(Min/+) mice drinking APE fed both diets and in wt mice fed WD. In normal mucosa, mice drinking water had lower global levels of DNA methylation than mice drinking APE. APE treatment is highly effective in reducing polyps in Apc(Min/+) mice and supports the concept that a mixture of phytochemicals, as they are naturally present in foods, represent a plausible chemopreventive agent for CRC, particularly in populations at high risk for colorectal neoplasia. |
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Authors:
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Lucia Fini; Giulia Piazzi; Yahya Daoud; Michael Selgrad; Shinji Maegawa; Melissa Garcia; Vincenzo Fogliano; Marco Romano; Giulia Graziani; Paola Vitaglione; Susanne W Carmack; Antonio Gasbarrini; Robert M Genta; Jean-Pierre J Issa; C Richard Boland; Luigi Ricciardiello |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-7 |
Journal Detail:
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Title: Cancer prevention research (Philadelphia, Pa.) Volume: - ISSN: 1940-6215 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101479409 Medline TA: Cancer Prev Res (Phila) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Internal Medicine, Baylor Reseach Institute and Sammons Cancer Center, Baylor University Medical Center. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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