| Chemoprevention of colon cancer by Korean food plant components. | |
| | |
MedLine Citation:
|
PMID: 12628507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Inducible cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS/NOS-2) play pivotal roles as mediators of inflammation involved in early steps of carcinogenesis in certain organs. Therefore, chemoprevention is theoretically possible through inhibition of COX-2 and/or iNOS. In the present study, we examined the chemopreventive effects of indole-3-carbinol (I3C), a constituent of cruciferous vegetables (the family of Cruciferae) such as cabbages, cauliflowers and broccoli on the multiple intestinal neoplasia (Min) genetic mouse model, and on mouse colon carcinogenesis induced by azoxymethane (AOM). The consumption of cruciferous vegetables such as cabbage, broccoli, and Brussels sprouts has been shown to have cancer chemopreventive effects in humans and experimental animals. I3C has been shown to exert a cancer chemopreventive influence in liver, colon, and mammary tissue when given before or concurrent with exposure to a carcinogen. Powdered AIN-76A diets (Harlan Teklad Research Diet, Madison, USA) containing 100 or 300 ppm I3C (group 1 or 2) or the same pellet diets without supplement (group 3) were fed to 6-week-old male C57BL/6J-Apc(Min)(/+) (Min/+) mice (The Jackson Laboratory, Bar Harbor, ME, USA) for 10 weeks. In addition the same diets were given to wild-type normal C57BL/6J-Apc(Min)(/+) littermates after AOM initiation (groups 4-7: 10 mice in each group) for 32 weeks from week 4. At 16 weeks of age, all Min/+ mice (groups 1-3) were sacrificed for assessment of intestinal polyp development. The incidences of the colonic adenomatous polyps in the groups 1-3 were 60% (12/20), 60% (15/25) and 84% (21/25), respectively. A decreasing tendency in multiplicities of the colonic adenomatous polyps in group 1 (I3C 100 ppm; 0.85 +/- 0.22; 61%) and group 2 (I3C 300 ppm; 1.32 +/- 0.28; 94%) was observed when compared with group 3 (control; 1.40 +/- 0.21; 100%). Total number of aberrant crypt foci (ACF)/colon or aberrant crypts (AC)/colon in wild-type mice of group 4 or 5 were decreased significantly compared with those of the AOM alone group (group 6) (P < 0.01). These results suggest that I3C may be a potential chemopreventive agent for colon cancer. |
| | |
Authors:
|
Dae Joong Kim; Dong Hwan Shin; Byeongwoo Ahn; Jin Seok Kang; Ki Taek Nam; Cheol Beom Park; Cheul Kyu Kim; Jin Tae Hong; Yun-Bae Kim; Young Won Yun; Dong Deuk Jang; Ki-Hwa Yang |
Related Documents
:
|
3938837 - The interaction of dietary fat and antiestrogen treatment on dmba-induced mammary tumor... 9498277 - Effect of bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-... 23105457 - Lipoprotein (a): better assessor of coronary heart disease risk in south indian populat... 12807737 - Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in s... 20045457 - Photoperiod modulates gut bacteria composition in male siberian hamsters (phodopus sung... 23557217 - Radiation mitigating properties of the lignan component in flaxseed. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Mutation research Volume: 523-524 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 2003 Feb-Mar |
Date Detail:
|
Created Date: 2003-03-11 Completed Date: 2003-04-24 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 99-107 Citation Subset: IM |
Copyright Information:
|
Copyright 2002 Elsevier Science B.V. |
Affiliation:
|
Structural BioInformatics & Cancer Prevention, College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungbuk National University, 48 Gaeshin-dong, Heungduk-gu, Cheongju 361-763, South Korea. kimdj@cbu.ac.kr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anticarcinogenic Agents / therapeutic use* Azoxymethane Carcinogens Colonic Neoplasms / chemically induced, prevention & control* Cyclooxygenase Inhibitors / therapeutic use* Disease Models, Animal Genes, APC Intestinal Polyps / prevention & control Korea Male Mice Mice, Mutant Strains Phytotherapy* Plant Structures* Vegetables |
| Chemical | |
Reg. No./Substance:
|
0/Anticarcinogenic Agents; 0/Carcinogens; 0/Cyclooxygenase Inhibitors; 25843-45-2/Azoxymethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract.
Next Document: Potential functional foods in the traditional Maori diet.