Document Detail

Chemonucleolysis in the treatment of sciatica from herniated lumbar disc (author's transl)
MedLine Citation:
PMID:  7050900     Owner:  NLM     Status:  MEDLINE    
A proteolytic enzyme was used to dissolve the nucleus pulposus in 140 cases of sciatica from herniated lumbar disc. The results were satisfactory in 75% of 120 patients followed up for more than 6 months. This percentage of success, similar to that obtained with surgical excision of the disc, can only be achieved with a rigourous technique and, more importantly, with strict selection of the patients. Chemonucleolysis is indicated only for patients with unquestionable clinical and radiological evidence of herniated disc, in which case it can be considered as the ultimate medical treatment of sciatica associated with this lesion. No serious complications were observed in our series, but the risk of allergic reaction must be borne in mind.
M Benoist; A Deburge; A Rigod; J Busson; J Cauchoix
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  La Nouvelle presse médicale     Volume:  11     ISSN:  0301-1518     ISO Abbreviation:  Nouv Presse Med     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0312552     Medline TA:  Nouv Presse Med     Country:  FRANCE    
Other Details:
Languages:  fre     Pagination:  2121-4     Citation Subset:  IM    
Vernacular Title:
La chimionucléolyse dans le traitement des sciatiques discales. 120 observations.
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MeSH Terms
Intervertebral Disk Displacement / complications,  drug therapy*
Lumbar Vertebrae
Middle Aged
Peptide Hydrolases / therapeutic use*
Sciatica / etiology,  therapy*
Time Factors
Reg. No./Substance:
EC 3.4.-/Peptide Hydrolases

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