Document Detail

Chemonucleolysis failures treated by PLIF.
MedLine Citation:
PMID:  3882299     Owner:  NLM     Status:  MEDLINE    
Chemonucleolysis is a procedure in which an enzyme is injected into the intervertebral disc for the purpose of alleviating sciatic pain. This has a reported success rate of 70%-90%. Of the failures, several will benefit from a classic lumbar laminectomy for removal of a free fragment in the spinal canal caused by either improper technique or inadequate enzyme activity. However, in a significant number of cases, the failure is related to either instability or the compression of the nerve roots in the neural foramen. Observations on 17 cases demonstrate that PLIF can relieve pain and other symptoms in cases of failed chemonucleolysis.
R Sepulveda; A P Kant
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-10     Completed Date:  1985-04-10     Revised Date:  2005-03-03    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-74     Citation Subset:  AIM; IM    
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MeSH Terms
Chymopapain / administration & dosage,  therapeutic use*
Endopeptidases / therapeutic use*
Intervertebral Disk Displacement / drug therapy*,  surgery
Joint Instability / etiology
Lumbar Vertebrae / radiography,  surgery
Postoperative Complications
Spinal Fusion / methods*
Reg. No./Substance:
EC 3.4.-/Endopeptidases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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