| Chemonucleolysis (discolysis) with collagenase. | |
| | |
MedLine Citation:
|
PMID: 3010478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fifty-four patients with proven lumbar disc displacement were treated by intradiscal injection of collagenase (Nucleolysin) between April 1981 and January 1984. Follow-up by history and physical examination, phone survey, and/or mail survey shows 72% success rate (excellent, good, and fair) and 28% poor or unsuccessful results. No patient was made worse by the treatment. Success rate was greater in patients older than the age of 50 years, male patients, and patients with pain complaints of longer than 4 months' duration. The presence of a list and/or crossed straight leg raising and/or straight leg raising positive less than 30 degrees was associated with a poor prognosis. Discography prior to collagenase injection did not compromise the outcome of treatment. Postinjection changes in the CT scan correlated with a satisfactory outcome of treatment. Findings at surgery in patients who failed to obtain relief following collagenase injection did not show a specific deleterious effect of the enzyme, nor were the expected results from surgery compromised by a previous unsuccessful intradiscal collagenase injection. |
| | |
Authors:
|
M D Brown; J S Tompkins |
Related Documents
:
|
8198238 - Booster immunotherapy (bit). 19641918 - Use of platelet-rich plasma for the treatment of refractory jumper's knee. 14601898 - Long-term follow-up of achalasic patients treated with botulinum toxin. 2197438 - Submucosal injection of polyvinyl alcohol foam in rabbit bladder. 20951258 - In situ pericardial extracardiac lateral tunnel fontan operation: fifteen-year experience. 2963538 - Prospective evaluation of a dacron cuffed hemodialysis catheter for prolonged use. |
Publication Detail:
|
Type: Case Reports; Clinical Trial; Journal Article |
Journal Detail:
|
Title: Spine Volume: 11 ISSN: 0362-2436 ISO Abbreviation: Spine Publication Date: 1986 Mar |
Date Detail:
|
Created Date: 1986-06-10 Completed Date: 1986-06-10 Revised Date: 2009-07-09 |
Medline Journal Info:
|
Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 123-30 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Clinical Trials as Topic Female Follow-Up Studies Humans Intervertebral Disk Displacement / diagnosis, drug therapy*, surgery Length of Stay Lumbar Vertebrae Male Microbial Collagenase / adverse effects, therapeutic use* Middle Aged Physical Examination Time Factors Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
|
EC 3.4.24.3/Microbial Collagenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection and quantitation of fetomaternal hemorrhage.
Next Document: Primary hepatocellular carcinoma in pregnancy. A case report.