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Chemometric approach for investigating the skin surface lipids (SSLs) composition: influence of geographical localization.
MedLine Citation:
PMID:  21628132     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Skin surface lipids (SSLs), arising from both sebaceous glands and skin removal, form a complex lipid mixture composed of free fatty acids and neutral lipids. They are present in the hydrolipidic film and have a close relationship with the stratum corneum lipids. Thus, SSLs participate in the barrier function. One can expect a physiological adaptation of the SSLs composition according to geographical localization or skin pigmentation. In this study, SSLs obtained from three groups of volunteers (light and dark skin, living in France and dark skin, living in Ivory Coast) have been investigated. High-temperature gas chromatography/mass spectrometry has been used to study SSLs composition. The variability in the SSLs chromatographic profiles has been investigated, using chemometric methods which allowed us to highlight the sapienic acid (C16: 1Δ6) as discriminant according to geographical localization. This result is of a great interest regarding sapienic acid properties. However, no significant variation has been detected following skin pigmentation. In parallel, SSLs Raman spectra were collected in order to determine the organization and the conformational order of lipids. The spectral data treatment revealed discriminant variation in the υ C-C stretching region revealing changes in the conformational order of the SSLs following geographical localization.
Authors:
Rime Michael-Jubeli; Ali Tfayli; Jean Bleton; Arlette Baillet-Guffroy
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  21     ISSN:  1167-1122     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-6-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  63-71     Citation Subset:  -    
Affiliation:
EA 4041, Paris-Sud Analytical Chemistry Group, Faculty of Pharmacy, University of Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, FranceEA 4041, Paris-Sud Analytical Chemistry Group, Faculty of Pharmacy, University of Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France.
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