Document Detail


Chemokines and pro-inflammatory cytokines in Down's syndrome: an early marker for Alzheimer-type dementia?
MedLine Citation:
PMID:  12097789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: People with Down's syndrome (DS) show early Alzheimer-like dementia. It has been suggested that the pro-inflammatory cytokine class plays a role in Alzheimer's disease (AD). The study aims at verifying whether pro-inflammatory cytokines in DS are correlated with age, affective symptoms and intellectual decline to a different degree than in subjects with non-DS learning disabilities.
METHODS:
CASES: 19 subjects with DS; controls: sex- and age-matched individuals with learning disabilities caused by perinatal ischaemic damage. The level of mental retardation was assessed according to DSM-IV; psychopathological symptoms were measured by the Assessment and Information Rating Profile. Serum levels of cytokines were determined with ELISA.
RESULTS: DS patients showed higher levels of cytokines and chemokines, with the exception of RANTES; but the only significant difference detected was for MIP-1alpha. A correlation between the degree of mental retardation and IL-6, and between MIP-lalpha and age was found in patients with DS, but not in controls.
CONCLUSIONS: The data obtained suggest a possible involvement of chemokines in the inflammatory and degenerative processes similar to AD in DS. Further longitudinal research is required to confirm these findings.
Authors:
Mauro G Carta; Paolo Serra; Assunta Ghiani; Elisabetta Manca; Maria Carolina Hardoy; Gennaro S Del Giacco; Giacomo Diaz; Bernardo Carpiniello; Paolo E Manconi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychotherapy and psychosomatics     Volume:  71     ISSN:  0033-3190     ISO Abbreviation:  Psychother Psychosom     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-07-04     Completed Date:  2002-10-09     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0024046     Medline TA:  Psychother Psychosom     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  233-6     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
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MeSH Terms
Descriptor/Qualifier:
Adult
Alzheimer Disease / metabolism*
Amyloid beta-Protein Precursor / metabolism
Biological Markers
Chemokines / blood,  metabolism*
Cross-Sectional Studies
Cytokines / blood,  metabolism*
Down Syndrome / metabolism*
Female
Humans
Male
Time Factors
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein Precursor; 0/Biological Markers; 0/Chemokines; 0/Cytokines

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