Document Detail


Chemokines and other mediators as therapeutic targets in psoriasis vulgaris.
MedLine Citation:
PMID:  18755373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years, our knowledge of the immunopathogenesis of chronic inflammatory skin diseases has increased significantly. Accumulating evidence indicates that the complex interaction of structural cells, in particular keratinocytes and endothelial cells, with skin-infiltrating leukocytes is key to our understanding of psoriasis. The recruitment of pathogenic leukocyte subsets into the skin represents a prerequisite for the initiation and maintenance of psoriasis vulgaris and is mediated by a complex chemokine and cytokine network. Results of recent studies associating cytokines and chemokines with a psoriatic phenotype are outlined herein, and their role as therapeutic targets in psoriasis is discussed in detail.
Authors:
Bernhard Homey; Stephan Meller
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in dermatology     Volume:  26     ISSN:  0738-081X     ISO Abbreviation:  Clin. Dermatol.     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-08-29     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406412     Medline TA:  Clin Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-45     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Heinrich-Heine-University, Moorenstr. 5, 40225 Düsseldorf, Germany.
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MeSH Terms
Descriptor/Qualifier:
Cell Communication
Chemokines / immunology*,  metabolism
Cytokines / immunology*,  metabolism
Humans
Metabolic Networks and Pathways
Psoriasis / drug therapy*,  immunology,  metabolism
Chemical
Reg. No./Substance:
0/Chemokines; 0/Cytokines

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