Document Detail

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure.
MedLine Citation:
PMID:  22532075     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Chemokines and mitochondrial products (e.g., formyl peptides and mitDNA) collaborate in neutrophil-mediated injury and systemic inflammation during acute liver failure. Hepatocyte death is amplified by liver neutrophil infiltration, and the release of necrotic products into the circulation may trigger a systemic inflammatory response and remote lung injury.
Pedro E Marques; Sylvia S Amaral; Daniele A Pires; Laura L Nogueira; Frederico M Soriani; Braulio H F Lima; Gabriel A O Lopes; Remo C Russo; Thiago V Avila; Juliana G Melgaço; André G Oliveira; Marcelo A Pinto; Cristiano X Lima; Ana Maria De Paula; Denise C Cara; Maria F Leite; Mauro M Teixeira; Gustavo Batista Menezes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-21
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  56     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-01     Completed Date:  2013-01-15     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1971-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
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MeSH Terms
Acute Lung Injury / blood,  immunology
Acute-Phase Reaction / immunology,  metabolism*
Analysis of Variance
Cell Movement
Chemokines / blood,  immunology,  metabolism*
Coculture Techniques
DNA, Mitochondrial / blood*
Hep G2 Cells
Interleukin-8 / blood
Liver / metabolism,  pathology*
Liver Failure, Acute / chemically induced,  immunology*
Mice, Inbred C57BL
Mice, Knockout
Middle Aged
Mitochondrial Proteins / immunology,  metabolism
Necrosis / immunology
Neutrophils / immunology*
Receptors, Formyl Peptide / immunology,  metabolism*
Receptors, Interleukin-8B / blood,  immunology,  metabolism
Signal Transduction
Systemic Inflammatory Response Syndrome / blood,  immunology
Toll-Like Receptor 9 / genetics,  immunology
Young Adult
Reg. No./Substance:
0/Chemokines; 0/DNA, Mitochondrial; 0/Fpr1 protein, mouse; 0/Interleukin-8; 0/Mitochondrial Proteins; 0/Receptors, Formyl Peptide; 0/Receptors, Interleukin-8B; 0/Toll-Like Receptor 9; 103-90-2/Acetaminophen
Comment In:
Hepatology. 2013 Jan;57(1):420-1   [PMID:  22707302 ]
Hepatology. 2013 Jan;57(1):419   [PMID:  22707002 ]
Hepatology. 2012 Nov;56(5):1599-601   [PMID:  22729522 ]

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