| Chemokines in autoimmunity: from pathology to therapeutics. | |
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MedLine Citation:
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PMID: 12848986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leukocyte recruitment, accumulation, and activation have been both a unifying and enigmatic feature of a variety of autoimmune pathologies. While these processes were not well-known for decades, recent scientific discoveries have underscored the importance of specific chemokines in the evolution of autoimmunity. This has been supported by in vivo data from clinical studies and animal model experiments. Although chemokines are an attractive target for drug development, there are hurdles that need to be cleared. Nonetheless, the quest to understand chemokine biology and develop effective therapies continues to capture the imagination of scientists in academia and pharma alike. |
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Authors:
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Steven L Kunkel; Nuria Godessart |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Autoimmunity reviews Volume: 1 ISSN: 1568-9972 ISO Abbreviation: Autoimmun Rev Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-07-09 Completed Date: 2003-08-27 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 101128967 Medline TA: Autoimmun Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 313-20 Citation Subset: IM |
Affiliation:
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Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases / etiology, immunology, therapy Autoimmunity* Chemokines / immunology* Humans Inflammation Mediators / immunology Models, Immunological |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/Inflammation Mediators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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