| Chemokines and chemokine receptors: New actors in neuroendocrine regulations. | |
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MedLine Citation:
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PMID: 20624414 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells. Their role in the immune system is well-known, and it has recently been suggested that they may also play a role in the central nervous system (CNS). Indeed, they do not only act as immunoinflammatory mediators in the brain but they also act as potential modulators in neurotransmission. Although we are only beginning to be aware of the implication of chemokines in neuroendocrine functions, this review aims at summarizing what is known in that booming field of research. First we describe the expression of chemokines and their receptors in the CNS with a focus on the hypothalamo-pituitary system. Secondly, we present what is known on some chemokines in the regulation of neuroendocrine functions such as cell migration, stress, thermoregulation, drinking and feeding as well as anterior pituitary functions. We suggest that chemokines provide a fine modulatory tuning system of neuroendocrine regulations. |
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Authors:
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William Rostène; Alice Guyon; Lara Kular; David Godefroy; Federica Barbieri; Adriana Bajetto; Ghazal Banisadr; Céline Callewaere; Gregory Conductier; Carole Rovère; Stéphane Mélik-Parsadaniantz; Tullio Florio |
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Publication Detail:
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Type: Journal Article Date: 2010-07-17 |
Journal Detail:
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Title: Frontiers in neuroendocrinology Volume: 32 ISSN: 1095-6808 ISO Abbreviation: Front Neuroendocrinol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513292 Medline TA: Front Neuroendocrinol Country: United States |
Other Details:
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Languages: eng Pagination: 10-24 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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INSERM-UPMC UMRS 732, Hôpital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, 75571 Paris Cedex 12, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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