Document Detail

Chemokines and B cells in renal inflammation and allograft rejection.
MedLine Citation:
PMID:  19482678     Owner:  NLM     Status:  MEDLINE    
Recently the presence of intrarenal B cells in various inflammatory kidney diseases has been described and was in some cases linked to an unfavourable clinical course. Mechanisms leading to B cell influx into the kidney have therefore gained interest. Available data from the literature will be reviewed here with special focus on the contribution of chemokines. By far the most data from animal studies and human biopsies exist for BCA-1/CXCL13 pointing to a central role for this chemokine in B cell trafficking via interaction with its corresponding receptor CXCR5 on the B cell surface. Future studies will help to improve the knowledge on functional importance of B cell attracting chemokines as well as clinical significance of intrarenal B cell infiltrates.
Oliver M Steinmetz; Rolf A K Stahl; Ulf Panzer
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-06-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  1     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-01     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-22     Citation Subset:  IM    
III. Medizinische Klinik, Zentrum fur Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
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MeSH Terms
B-Lymphocytes / immunology*
Chemokines / physiology*
Graft Rejection*
Kidney Transplantation*
Nephritis / immunology*,  physiopathology
Reg. No./Substance:

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