Document Detail


Chemokines and B cells in renal inflammation and allograft rejection.
MedLine Citation:
PMID:  19482678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently the presence of intrarenal B cells in various inflammatory kidney diseases has been described and was in some cases linked to an unfavourable clinical course. Mechanisms leading to B cell influx into the kidney have therefore gained interest. Available data from the literature will be reviewed here with special focus on the contribution of chemokines. By far the most data from animal studies and human biopsies exist for BCA-1/CXCL13 pointing to a central role for this chemokine in B cell trafficking via interaction with its corresponding receptor CXCR5 on the B cell surface. Future studies will help to improve the knowledge on functional importance of B cell attracting chemokines as well as clinical significance of intrarenal B cell infiltrates.
Authors:
Oliver M Steinmetz; Rolf A K Stahl; Ulf Panzer
Related Documents :
8764978 - Insulin restores the calcium-activated chloride conductance in dedifferentiated renal g...
7020428 - The growth of primary glomerular cells as a confluent monolayer in a chemically defined...
10792778 - Quantitative estimation of renin-containing cells in the juxtaglomerular apparatus in b...
8210558 - Interstitial leucocyte infiltration in primary glomerulonephritis: extent and compositi...
5441028 - Shear dependence of effective cell volume as a determinant of blood viscosity.
11989968 - Hydroxyl free radicals induce cell differentiation in sk-n-mc neuroblastoma cells.
Publication Detail:
Type:  Journal Article; Review     Date:  2009-06-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  1     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-01     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-22     Citation Subset:  IM    
Affiliation:
III. Medizinische Klinik, Zentrum fur Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. o.steinmetz@uke.uni-hamburg.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
B-Lymphocytes / immunology*
Chemokines / physiology*
Graft Rejection*
Humans
Kidney Transplantation*
Nephritis / immunology*,  physiopathology
Chemical
Reg. No./Substance:
0/Chemokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chemokines and chemokine receptors as therapeutic targets in chronic kidney disease.
Next Document:  Tendon tissue engineering with mesenchymal stem cells and biografts: an option for large tendon defe...