Document Detail


Chemokine Regulation of Immune-mediated Demyelinating Disease.
MedLine Citation:
PMID:  11406697     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1-mediated demyelinating disease of the central nervous system (CNS), which serves as a model for multiple schlerosis (MS). A hallmark in the pathogenesis of this disease is the emigration of T cells and monocytes from the blood to the CNS. Chemokines are small-molecular-weight chemotactic peptides, which are ligands for seven transmembrane-spanning, G protein-coupled receptors and which deliver signals leading to a variety of T cell functions including costimulation, cytokine expression, differentiation, and integrin activation. Several considerations suggest a role for chemokines in the influx of inflammatory cells to the CNS and the resulting disease process, including a tight temporal expression pattern with a relation to disease activity and prevention of disease development by in vivo neutralization. This article reviews the evidence that temporal and spatial expressions of chemokines are critical factors that regulate EAE, which makes this an appropriate animal model to study the pathogenesis of MS disease activity.
Authors:
William J. Karpus; Kevin J. Kennedy; Brian T. Fife; Lisa M. Hoffman
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  ILAR journal / National Research Council, Institute of Laboratory Animal Resources     Volume:  40     ISSN:  1930-6180     ISO Abbreviation:  ILAR J     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2001-Jun-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516416     Medline TA:  ILAR J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  183-189     Citation Subset:  -    
Affiliation:
Department of Pathology, Northwestern University Medical School, Chicago, Illinois, USA.
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