Document Detail

Chemoenzymatic conversion of linoleic acid into conjugated linoleic acid.
MedLine Citation:
PMID:  20058923     Owner:  NLM     Status:  MEDLINE    
An efficient chemoenzymatic method for preparing conjugated linoleic acid (CLA) using free linoleic acid (LA) as a substrate is described. In the first step, LA was transformed into 10-hydroxy-cis-12-octadecenoic acid (HA) by the whole cells of Lactobacillus plantarum after 48 h of incubation. The preincubation of whole cells with 0.03% LA resulted in a better yield of HA (480 mg/g) compared to cells grown without LA. In a second fast microwave step, HA was converted to cis-9,trans-11-octadecadienoic acid in the presence of iodine as a catalyst over a silica gel surface. The advantage of this method in preparing cis-9,trans-11 CLA is simple via the whole cell bioconversion of LA into HA via L. plantarum followed by the fast microwave-assisted synthesis of cis-9,trans-11 CLA in higher yields.
Ayhan S Demir; Farah N Talpur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  58     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1646-52     Citation Subset:  IM    
Department of Chemistry, Middle East Technical University, 06531Ankara, Turkey.
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MeSH Terms
Bacterial Proteins / metabolism*
Lactobacillus plantarum / enzymology,  metabolism*
Linoleic Acid / chemistry,  metabolism*
Linoleic Acids, Conjugated / chemistry,  metabolism*
Oleic Acids / chemistry,  metabolism
Reg. No./Substance:
0/Bacterial Proteins; 0/Linoleic Acids, Conjugated; 0/Oleic Acids; 2197-37-7/Linoleic Acid; 7378-88-3/12-octadecenoic acid

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