Document Detail

Chemoattraction of inflammatory cells by various intraocular lens materials.
MedLine Citation:
PMID:  16321887     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the chemotactic activity induced by polymethyl methacrylate (PMMA), acrylic, and silicone intraocular lens (IOL) materials, regardless of the surgical and host factors. METHODS: The chemotactic effect of five different IOLs was studied using a modified multi-well Boyden chamber. Two different non-coated PMMA IOLs, a heparin-coated PMMA IOL, an acrylic IOL, and a silicone IOL were assessed. Each mean migration distance of the IOLs was compared with the others using Student's t test. RESULTS: All IOLs induced some amount of leukocyte chemotaxis. There was no statistically significant difference between the chemotactic activity of PMMA IOLs. However, chemotactic activity was significantly higher in acrylic (p<0.05) and silicone (p<0.05) IOLs compared to one of the PMMA lenses. CONCLUSIONS: This limited study has proven that chemotaxis assay is a useful tool to assess the biocompatibility of IOLs. The IOL material itself might attract inflammatory cells to its surface in the absence of surgical and host factors. As PMMA IOLs do not cause an increase in inflammatory reaction, they may be considered safe to use. Further improvement in chemical composition and surface characteristics of IOLs should reduce the inflammatory reaction and increase the biocompatibility and safety of IOLs.
Pinar C Ozdal; Emilia Antecka; Malcolm G Baines; Raul N G Vianna; Marcello Rudzinski; Jean Desch?nes
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  13     ISSN:  0927-3948     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-02     Completed Date:  2006-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  435-8     Citation Subset:  IM    
Department of Ophthalmology, McGill University, Montr?al, Qu?bec, Canada.
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MeSH Terms
Acrylic Resins*
Chemotaxis, Leukocyte / physiology*
Lenses, Intraocular*
Polymethyl Methacrylate*
Silicone Elastomers*
Reg. No./Substance:
0/Acrylic Resins; 0/Silicone Elastomers; 9011-14-7/Polymethyl Methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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