Document Detail


Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children.
MedLine Citation:
PMID:  19157546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sensitivity to 10 anticancer drugs was evaluated in 6 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cell lines. Authenticity of newly established cell lines was confirmed by genomic fingerprinting. The line YCUB-5R established at relapse was more resistant to 4-hydroperoxy-cyclophosphamide, cytarabine, L-asparaginase, topotecan, fludarabine, and etoposide than YCUB-5 from the same patient at diagnosis. Of the drugs tested, etoposide and SN-38 (irinotecan) showed highest efficacy in the panel, with 50% growth inhibition at 0.22-1.8 microg/ml and 0.57-3.6 ng/ml, respectively. This cell line panel offers an in vitro model for the development of new therapies for childhood BCP-ALL.
Authors:
Hiroaki Goto; Takuya Naruto; Reo Tanoshima; Hiromi Kato; Tomoko Yokosuka; Masakatsu Yanagimachi; Hisaki Fujii; Shumpei Yokota; Hiromi Komine
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-20
Journal Detail:
Title:  Leukemia research     Volume:  33     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1386-91     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Yokohama City University Hospital, 3-9 Fukuura Kanazawa-ku, Yokohama 236-0044, Japan. hgoto39@med.yokohama-cu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / therapeutic use
B-Lymphocytes / pathology*
Cell Division / drug effects
Cell Line, Tumor / drug effects
Cell Survival / drug effects
Child
Child, Preschool
DNA Fingerprinting / methods*
Flow Cytometry
Humans
Immunophenotyping
Leukocyte Count
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood,  drug therapy,  genetics*,  pathology
Prednisolone / pharmacology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 50-24-8/Prednisolone

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