| Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children. | |
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MedLine Citation:
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PMID: 19157546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sensitivity to 10 anticancer drugs was evaluated in 6 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cell lines. Authenticity of newly established cell lines was confirmed by genomic fingerprinting. The line YCUB-5R established at relapse was more resistant to 4-hydroperoxy-cyclophosphamide, cytarabine, L-asparaginase, topotecan, fludarabine, and etoposide than YCUB-5 from the same patient at diagnosis. Of the drugs tested, etoposide and SN-38 (irinotecan) showed highest efficacy in the panel, with 50% growth inhibition at 0.22-1.8 microg/ml and 0.57-3.6 ng/ml, respectively. This cell line panel offers an in vitro model for the development of new therapies for childhood BCP-ALL. |
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Authors:
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Hiroaki Goto; Takuya Naruto; Reo Tanoshima; Hiromi Kato; Tomoko Yokosuka; Masakatsu Yanagimachi; Hisaki Fujii; Shumpei Yokota; Hiromi Komine |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-20 |
Journal Detail:
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Title: Leukemia research Volume: 33 ISSN: 1873-5835 ISO Abbreviation: Leuk. Res. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-07-06 Completed Date: 2009-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 1386-91 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Yokohama City University Hospital, 3-9 Fukuura Kanazawa-ku, Yokohama 236-0044, Japan. hgoto39@med.yokohama-cu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use B-Lymphocytes / pathology* Cell Division / drug effects Cell Line, Tumor / drug effects Cell Survival / drug effects Child Child, Preschool DNA Fingerprinting / methods* Flow Cytometry Humans Immunophenotyping Leukocyte Count Male Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood, drug therapy, genetics*, pathology Prednisolone / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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