| Chemistry and biology of siderophores. | |
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MedLine Citation:
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PMID: 20376388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Siderophores are compounds produced by bacteria, fungi and graminaceous plants for scavenging iron from the environment. They are low-molecular-weight compounds (500-1500 daltons) possessing a high affinity for iron(III) (Kf > 1030), the biosynthesis of which is regulated by iron levels and the function of which is to supply iron to the cell. This article briefly describes the classification and chemical properties of siderophores, before outlining research on siderophore biosynthesis and transport. Clinically important siderophores and the therapeutic potential of siderophore design are described. Appendix 1 provides a comprehensive list of siderophore structures. |
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Authors:
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Robert C Hider; Xiaole Kong |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Natural product reports Volume: 27 ISSN: 1460-4752 ISO Abbreviation: Nat Prod Rep Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-05 Completed Date: 2010-06-04 Revised Date: 2011-06-07 |
Medline Journal Info:
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Nlm Unique ID: 8502408 Medline TA: Nat Prod Rep Country: England |
Other Details:
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Languages: eng Pagination: 637-57 Citation Subset: IM |
Affiliation:
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Division of Pharmaceutical Science, King's College, London, SE1 9NH, UK. robert.hider@kcl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteria
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chemistry Fungi / chemistry Iron / metabolism* Molecular Structure Plants / chemistry Siderophores* / chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Siderophores; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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