Document Detail

Chemistry and biology of nitrosated peptides.
MedLine Citation:
PMID:  2696585     Owner:  NLM     Status:  MEDLINE    
All peptides undergo nitrosation at the terminal primary amino group to generate a diazopeptide and at the peptide N-atoms to produce an N-nitrosopeptide. With acidified nitrite, diazopeptides usually form more readily than N-nitrosopeptides, but quickly decompose. Diazopeptides form rapidly at neutral pH from gaseous nitrogen oxides and are relatively stable under these conditions. N-nitrosopeptides are more stable than diazopeptides at both acidic and neutral pH. Because of their availability as substrates, peptides are probably involved in endogenous nitrosation associated with the diet and from the inhalation of nitrogen oxides as in tobacco smoking. Both diazopeptides and N-nitrosopeptides are cytotoxic, but a causal role for these compounds in human cancer has yet to be demonstrated.
B C Challis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cancer surveys     Volume:  8     ISSN:  0261-2429     ISO Abbreviation:  Cancer Surv.     Publication Date:  1989  
Date Detail:
Created Date:  1990-04-03     Completed Date:  1990-04-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8218015     Medline TA:  Cancer Surv     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  363-84     Citation Subset:  IM    
Chemistry Department, Open University, Milton Keynes.
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MeSH Terms
Chemical Phenomena
Mutagenicity Tests
Nitroso Compounds / chemical synthesis*,  pharmacology
Reg. No./Substance:
0/Nitroso Compounds; 0/Peptides

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