| Chemistry and biological activity of AAL toxins. | |
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MedLine Citation:
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PMID: 8850626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AAL toxins and fumonisins comprise a family of highly reactive, chemically related mycotoxins that disrupt cellular homeostasis in both plant and animal tissues. Two critical issues to resolve are the detection of the entire family in food matricies and the mode of cellular disruption. Analysis of the entire set of chemical congeners in food matrices is difficult but has been achieved by a combination of different HPLC and mass spectrometry strategies. The mode of cellular disruption is unknown but likely involves changes associated with the inhibition of ceramide synthase in both plants and animals. Toxin treated cells exhibit morphological and biochemical changes characteristic of apoptosis. Further evaluation of the specific genetic and biochemical changes that occur during toxin-induced cell death may aid in understanding the mole of the action of these mycotoxins. |
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Authors:
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C K Winter; D G Gilchrist; M B Dickman; C Jones |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 392 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1996 |
Date Detail:
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Created Date: 1996-12-11 Completed Date: 1996-12-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 307-16 Citation Subset: IM |
Affiliation:
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Department of Food Science and Technology, University of California, Davis 95616, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alternaria*
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metabolism Amidohydrolases / antagonists & inhibitors Animals Cell Death Ceramidases Enzyme Inhibitors Humans Molecular Structure Mycotoxins / analysis, chemistry*, pharmacology* Plant Diseases |
| Grant Support | |
ID/Acronym/Agency:
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IP30ES05707/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Mycotoxins; EC 3.5.-/Amidohydrolases; EC 3.5.1.23/Ceramidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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