Document Detail


Chemistry and biological activity of AAL toxins.
MedLine Citation:
PMID:  8850626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AAL toxins and fumonisins comprise a family of highly reactive, chemically related mycotoxins that disrupt cellular homeostasis in both plant and animal tissues. Two critical issues to resolve are the detection of the entire family in food matricies and the mode of cellular disruption. Analysis of the entire set of chemical congeners in food matrices is difficult but has been achieved by a combination of different HPLC and mass spectrometry strategies. The mode of cellular disruption is unknown but likely involves changes associated with the inhibition of ceramide synthase in both plants and animals. Toxin treated cells exhibit morphological and biochemical changes characteristic of apoptosis. Further evaluation of the specific genetic and biochemical changes that occur during toxin-induced cell death may aid in understanding the mole of the action of these mycotoxins.
Authors:
C K Winter; D G Gilchrist; M B Dickman; C Jones
Related Documents :
11349306 - Botulinum toxin a and facial lines: the variable concentration.
9172356 - In vitro assay of staphylococcus aureus enterotoxin a activity in food.
319166 - The low prevalence of clostridium botulinum in the lakes, marshes and waterways of the ...
3891256 - Role of the mucosal barrier in toxin/microbial attachment to the gastrointestinal tract.
22510276 - Differential associations between the food environment near schools and childhood overw...
629216 - Zinc anc copper status of polynesian residents in the tokelau islands.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  392     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-16     Citation Subset:  IM    
Affiliation:
Department of Food Science and Technology, University of California, Davis 95616, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alternaria* / metabolism
Amidohydrolases / antagonists & inhibitors
Animals
Cell Death
Ceramidases
Enzyme Inhibitors
Humans
Molecular Structure
Mycotoxins / analysis,  chemistry*,  pharmacology*
Plant Diseases
Grant Support
ID/Acronym/Agency:
IP30ES05707/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Mycotoxins; EC 3.5.-/Amidohydrolases; EC 3.5.1.23/Ceramidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fumonisin toxicity and sphingolipid biosynthesis.
Next Document:  Distribution of fumonisins in food and feed products prepared from contaminated corn.