Document Detail

Chemistry and biochemistry of lipid peroxidation products.
MedLine Citation:
PMID:  20836659     Owner:  NLM     Status:  MEDLINE    
Oxidative stress and resulting lipid peroxidation is involved in various and numerous pathological states including inflammation, atherosclerosis, neurodegenerative diseases and cancer. This review is focused on recent advances concerning the formation, metabolism and reactivity towards macromolecules of lipid peroxidation breakdown products, some of which being considered as 'second messengers' of oxidative stress. This review relates also new advances regarding apoptosis induction, survival/proliferation processes and autophagy regulated by 4-hydroxynonenal, a major product of omega-6 fatty acid peroxidation, in relationship with detoxication mechanisms. The use of these lipid peroxidation products as oxidative stress/lipid peroxidation biomarkers is also addressed.
F Guéraud; M Atalay; N Bresgen; A Cipak; P M Eckl; L Huc; I Jouanin; W Siems; K Uchida
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Free radical research     Volume:  44     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1098-124     Citation Subset:  IM    
UMR1089 Xénobiotiques, INRA, Toulouse, France.
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MeSH Terms
Aldehydes / chemistry,  metabolism*
Biological Markers / metabolism
Lipid Peroxidation / physiology*
Oxidative Stress / physiology*
Reg. No./Substance:
0/Aldehydes; 0/Biological Markers; 29343-52-0/4-hydroxy-2-nonenal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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