Document Detail


Chemiluminescence phenomena in the ischemic heart muscle.
MedLine Citation:
PMID:  2029649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dog experiments were performed using the measurement of tissue chemiluminescence to clarify the peculiar role of reactive oxygen species in ischemic heart damage. Following left thoracotomy and pericardiotomy, the left anterior descending coronary artery (LAD) was ligated for 1, 2, 3 and 24 hours. Epicardial and endocardial muscle specimens were excised, homogenized, and centrifuged to detect chemiluminescent differences in the supernatants after t-butyl hydroperoxide induction at each time interval. Characteristic alterations were found between the infarcted region, border zone and intact area. The induced photoemission differed as to altered kinetics and intensity values. It is assumed that interrelations exist between the observed light burst and the actual scavenger state. Antioxidant administration advantageously modified the chemiluminescence effect, especially at the border zone. Induced chemiluminescence proved to be a good method to characterize ischemically altered myocardial cellular metabolism.
Authors:
B Török
Related Documents :
22234329 - Effects of a novel amiodarone-like compound sar114646a on the pig atrium and susceptibi...
22830029 - A model of left ventricular dysfunction complicated by caws arteritis in dba/2 mice.
22838189 - Cardiac indexes, cardiac damage biomarkers and energy expenditure in professional cycli...
2705649 - Increased production of oxygen free radicals by polymorphonuclear leukocytes in heart f...
7067059 - The effects of diltiazem and reduced serum ionized calcium on ischemic ventricular fibr...
1714409 - Elevated myocardial calcium and its role in sudden cardiac death.
12634889 - Are angiotensin ii receptor antagonists indicated in chronic heart failure?
11223439 - Relationship between serum lipoprotein(a) level and thrombin generation to the circadia...
7920329 - Electrophysiologic noninvasives parameters in patients with sick sinus syndrome and syn...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  92     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-06-20     Completed Date:  1991-06-20     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Affiliation:
Institute of Experimental Surgery, University School of Medicine, Pécs, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Disease / metabolism*
Dogs
Luminescent Measurements*
Myocardium / metabolism*
Peroxides / pharmacology
tert-Butylhydroperoxide
Chemical
Reg. No./Substance:
0/Peroxides; 75-91-2/tert-Butylhydroperoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Myocardial reperfusion and reperfusion injury: current views.
Next Document:  Vulnerability of specialized conductive tissue to ischemia and reperfusion related injury.