Document Detail

Chemiluminescence phenomena in the ischemic heart muscle.
MedLine Citation:
PMID:  2029649     Owner:  NLM     Status:  MEDLINE    
Dog experiments were performed using the measurement of tissue chemiluminescence to clarify the peculiar role of reactive oxygen species in ischemic heart damage. Following left thoracotomy and pericardiotomy, the left anterior descending coronary artery (LAD) was ligated for 1, 2, 3 and 24 hours. Epicardial and endocardial muscle specimens were excised, homogenized, and centrifuged to detect chemiluminescent differences in the supernatants after t-butyl hydroperoxide induction at each time interval. Characteristic alterations were found between the infarcted region, border zone and intact area. The induced photoemission differed as to altered kinetics and intensity values. It is assumed that interrelations exist between the observed light burst and the actual scavenger state. Antioxidant administration advantageously modified the chemiluminescence effect, especially at the border zone. Induced chemiluminescence proved to be a good method to characterize ischemically altered myocardial cellular metabolism.
B Török
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  92     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-06-20     Completed Date:  1991-06-20     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Institute of Experimental Surgery, University School of Medicine, Pécs, Hungary.
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MeSH Terms
Coronary Disease / metabolism*
Luminescent Measurements*
Myocardium / metabolism*
Peroxides / pharmacology
Reg. No./Substance:
0/Peroxides; 75-91-2/tert-Butylhydroperoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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